Biostatistics & Informatics Shared Resource

生物统计与信息学共享资源(BISR) 生物统计与信息学共享资源(BISR)在生物统计与信息学的研究活动中起着至关重要的作用 堪萨斯大学癌症中心(KUCC)支持KUCC调查人员的数据科学需求。 BISR由Byron Gajeski(CPC)博士和Devin Koestler(CB)博士共同领导，两人都已完成 长期致力于跨学科合作的生物统计学家。BISR包括19个 具有癌症生物统计学研究专业知识的教职员工，13名技术支持人员和 博士后研究员和三名行政工作人员，他们提供额外的技术和 管理专业知识，提高资源效率。BISR通过为KUCC调查人员提供 指导和指导研究设计、统计监督和分析、临床研究信息学和 数据管理、电子数据收集、生物信息学、复杂数据集(统计组学)分析，以及 研究人员发起的临床试验。 BISR由教职员工组成，他们的不同专业知识和技能组合涵盖了生物统计学领域， 生物信息学和信息学。这三个领域之间的大量重叠使研究人员能够 使用单一共享资源满足其数据收集、分析和统计分析需求。这个 数据科学领域之间的协同作用使BISR能够支持广泛的质量 以及时和具有成本效益的方式提供服务。为支持KUCC成员的研究活动， 这一资源的具体目标是：1)提供研究设计和统计支持及专门知识；2)提供 生物信息学和统计遗传学支持和专业知识；3)为数据收集提供信息学专业知识 和管理，以及开发和支持持续的研究支持技术、平台和 工具；以及4)对KUCC的学生、研究员和教职员工进行关于数据科学、可再生研究的教育 癌症研究中使用的想法和方法。从2016年到2020年，BISR支持69、60、85、80和78 分别是KUCC成员。2020年，癌症生物学的成员分别为18人、33人和27人， 癌症预防和控制、药物发现、药物输送和实验治疗 89个赠款申请(提交和重新提交)和161个项目(持续赠款、机构间信托基金和其他 项目)。此外，BISR在2020年支持了31名非成员癌症研究人员。适用于所有与癌症相关的 在项目方面，BISR在2020年支持了340个赠款申请和项目。2021年，CCSG的资金占到 ~BISR预算的10%，年直接支助投资回报约为60万美元 用于支持BISR教职员工的外部资金(占BISR支持的31%)。

BIOSTATISTICS AND INFORMATICS SHARED RESOURCE (BISR): ABSTRACT The Biostatistics and Informatics Shared Resource (BISR) plays an essential role in the research activities of The University of Kansas Cancer Center (KUCC) by supporting the data science needs of KUCC investigators. The BISR is co-led by Byron Gajewski (CPC), PhD, and Devin Koestler (CB), PhD, both accomplished biostatisticians with a long-standing commitment to cross-disciplinary collaborations. The BISR includes 19 faculty members with specialized cancer biostatistics research expertise, 13 technical support staff and postdoctoral fellows, and three administrative staff members who provide additional technical and administrative expertise, adding efficiency to the resource. The BISR assists KUCC investigators by providing guidance and direction in study design, statistical oversight and analyses, clinical research informatics and data management, electronic data collection, bioinformatics, complex data set (statistical ‘omics) analysis, and investigator-initiated clinical trials. The BISR consists of faculty and staff whose diverse expertise and skill sets span the areas of biostatistics, bioinformatics, and informatics. The considerable overlap between these three areas allows researchers to work with a single shared resource for their data collection, analytics, and statistical analysis needs. The synergy between the areas that encompass “data science” enables the BISR to support a wide range of quality services in a timely and cost-effective manner. To support the research activities of KUCC members, the specific aims of this resource are to: 1) provide study design and statistical support and expertise; 2) provide bioinformatics and statistical genetics support and expertise; 3) provide informatics expertise for data collection and management, as well as develop and support ongoing research enabling technologies, platforms, and tools; and 4) educate students, fellows and faculty members of KUCC on data science, reproducible research ideas, and methods used in cancer research. From 2016-2020, the BISR supported 69, 60, 85, 80, and 78 KUCC members respectively. In 2020, the breakdown was 18, 33, and 27 members from Cancer Biology, Cancer Prevention and Control, and Drug Discovery, Delivery and Experimental Therapeutics, respectively, on 89 grant applications (submissions and resubmissions) and 161 projects (ongoing grants, IITs, and other projects). In addition, the BISR supported 31 non-member cancer researchers in 2020. For all cancer-related projects, the BISR supported 340 grant applications plus projects in 2020. In 2021, CCSG funding accounts for ~10% of the BISR budget, with an annual direct support return on investment of approximately $0.6M dollars in external funding to support BISR faculty and staff (31% of BISR support).