Mechanisms of Amygdala-Mediated Memory Enhancement in Humans

项目摘要/摘要 直接电刺激杏仁核基底外侧复合体(BLA)可以改善 陈述性记忆，反映BLA在调节内侧颞叶记忆过程中的作用 (MTL)区域作为情绪唤醒的函数。因此，DES可以揭示BLA介导的记忆机制 与人类心理健康和疾病相关的增强。BLA的DES可以用来询问 记忆电路的功能，特别是MTL中的神经元振荡如何支持陈述性记忆。第一, 假设BLA能够优先处理最初遇到的信息的长期保留 在时间上相邻。第二，BLA优先投射到MTL前区域，因此被假设为 优先调制那些解剖区域中的记忆过程，被认为支持记忆的过程 对于空间位置而言，非空间项目比记忆更重要。第三，虽然情绪唤醒，杏仁核 活动、MTL活动和内存性能通常是相关的，我们假设DES将揭示 到其他MTL区域的BLA输出通过直接引发PRO-Memory来提高内存性能 这些网络中的振荡态。预期的结果代表着基本的 研究正常记忆功能的科学，并朝着旨在模仿的新疗法的重大进展 记忆增强的内生机制。

PROJECT SUMMARY/ABSTRACT Direct electrical stimulation (DES) of the basolateral complex of the amygdala (BLA) can improve declarative memory, reflecting the role of the BLA in modulating memory processes in medial temporal lobe (MTL) regions as a function of emotional arousal. Thus, DES can reveal mechanisms of BLA-mediated memory enhancement relevant to human mental health and disease. DES of the BLA can be used to interrogate the function of memory circuits, especially how neuronal oscillations in the MTL support declarative memory. First, BLA is hypothesized to wield the capacity to prioritize long-term retention of information initially encountered adjacent in time. Second, the BLA preferentially projects to anterior MTL regions and thus is hypothesized to preferentially modulate memory processes in those anatomic regions, processes thought to support memory for non-spatial items more so than memory for spatial locations. Third, although emotional arousal, amygdala activity, MTL activity, and memory performance are typically correlated, we hypothesize that DES will reveal that BLA outputs to other MTL regions cause improved memory performance by directly eliciting pro-memory oscillatory states in those networks. The expected outcomes represent a significant advancement for the basic science of normal memory function and significant movement towards novel therapeutics designed to emulate endogenous mechanisms of memory enhancement.