Biospecimen Processing and Biorepository

在本财政年度，BPC为130多项临床试验提供支持， 接收和处理超过50，000个生物样本，包括血液、尿液、脑脊髓 体液、胸腔积液抽吸物、腹水、唾液和骨髓抽吸物。该芯 负责管理和储存来自CCR诊所的样本。抵达后， 根据临床方案（根据标准操作规程）处理所有样品。 程序），条形码化并输入数据库，用于样品处理和储存目的， 编入软件系统BPC处理紧急的当天和例行样品运输 校内和校外的实验室。BPC提供广泛的服务 包括制定和验证标本处理、分析和 DNA提取，以建立优化标本完整性和一致性的方案。在 除了实验室服务外，该中心还为寻求建议的临床医生提供资源 研究设计，包括标本采集和储存方法以及所有 与数据和样本采集相关的方案相关研究报告。BPC提供 与样本处理、条形码和药代动力学（PK）储存相关的服务， 所有试验的药效学（PD）生物标本。工作人员为临床团队提供支持 在其议定书的整个生命周期内，包括协助确保 适当收集样本，并提供样本数据和装运日志。 在大流行期间，BPC提供了支持，并继续参与加工研究 用于COVID-19临床方案。

For the current fiscal year, the BPC provides support to over 130 clinical trials and receives and processes over 50,000 biological samples including blood, urine, cerebrospinal fluid, pleural effusion aspirate, ascites, saliva, and bone marrow aspirate. This Core is responsible for the management and repository of samples from the CCR clinics. Upon arrival, all samples are processed according to the clinical protocol (per standard operating procedures), barcoded and entered into a database for sample handling and storage purposes and cataloged into a software system. The BPC handles urgent same-day and routine sample shipments to both intramural and extramural laboratories. The BPC provides a broad range of services including the development and validation of procedures for specimen processing, analyses, and DNA extraction to establish protocols that optimize specimen integrity and consistency. In addition to laboratory services, the Core serves as a resource for clinicians seeking advice on study design including specimen collection and storage methods as well as all protocol-associated study worksheets related to data and sample collection. The BPC provides services related to sample processing, barcoding, and storage of pharmacokinetic (PK) and pharmacodynamic (PD) biospecimens for all trials. Staff provides support to clinical teams throughout the life cycle of their protocols including assistance with ensuring time-sensitive samples are collected appropriately and with provision of sample data and shipment logs. During the pandemic, the BPC provided support and remains involved in processing research bloods for COVID-19 clinical protocols.