Germline-Somatic Interactions and Association with Treatment Response in Cancer

在文献中考察“生殖系-躯体相互作用”的研究在定义“生殖系”、“躯体”和“相互作用”方面有着戏剧性的异质性。然而，很少有研究直接评估人类数据，也几乎没有研究开始描述与这些“生殖系-躯体相互作用”相关的治疗反应。我们假设，我们将能够根据在特定的治疗环境中在原发乳腺癌和转移性乳腺癌中同时出现生殖系/体细胞突变来确定与治疗反应的不同关联。

Studies examining "germline-somatic interaction" in the literature have dramatic heterogeneity in defining "germline," "somatic," and "interaction." However, few studies have directly evaluated human data, and almost no studies have begun to characterize treatment response associated with these "germline-somatic interactions." We hypothesize that we will be able to identify differential associations with treatment response based on co-occurrence of germline / somatic mutations in specific settings of treatment in primary breast cancer and metastatic breast cancer.