Biospecimen Core

项目摘要-Biospecimen核心 Biospecimen核心旨在为翻译研究工作提供专家支持 纪念斯隆·凯特琳癌症中心(MSK)胰腺孢子。核心将利用并扩展非常 MSK精密病理学的主动组织库计划和分子诊断能力 生物库核心(PPBC)，锚定4个其他MSK孢子和MSK胰腺癌中心 研究。孢子生物样品核心将在收集、注释、存储、 年登记患者的胰腺癌生物样本(组织和血液)的分布和跟踪 机构生物谱库方案和治疗研究方案。详细的生物样品 注释，包括分析前处理变量、病理结果和患者临床的文档 历史信息将记录在可靠的关系数据库中。我们将进行严格的数据质量 保证和质量控制措施，并对所有同意的患者进行标准化纵向随访 胰腺癌生物谱库中的材料。核心还将提供孢子调查人员 对肿瘤样本进行专家组织病理学评估，并协助执行和解释 免疫组织化学分析，选择组织进行显微解剖进行下游分析，构建组织 微阵列，并促进患者衍生的有机类化合物的创建。核心的具体目标是：(1)保持 并扩展用于胰腺癌研究的生物标本的收集、注释和存储，(2)执行 所有相关导管型胰腺癌标本的系统病理学评价及准备 适当的生物检验剂，供孢子调查人员使用；以及(3)提供系统显微镜 对治疗反应的评估。考虑到胰腺癌的显著异质性，每一种 AIMS需要现有资源无法提供的专业知识，这突出了对这一核心的需要。全 的研究项目将广泛依赖Biosecimen Core来实现他们的翻译研究 目标。

PROJECT SUMMARY – BIOSPECIMEN CORE The Biospecimen Core is designed to provide expert support to the translational research efforts of the Memorial Sloan Kettering Cancer Center (MSK) Pancreas SPORE. The Core will leverage and extend the very active tissue banking program and molecular diagnostics capabilities of the MSK Precision Pathology Biobanking Core (PPBC), which anchors 4 other MSK SPOREs and the MSK Center for Pancreatic Cancer Research. The SPORE Biospecimen Core will play an essential role in collection, annotation, storage, distribution, and tracking of pancreatic cancer biospecimens (tissue and blood) from patients enrolled in institutional biospecimen banking protocols and therapeutic research protocols. Detailed biospecimen annotation, including documentation of preanalytic processing variables, pathology findings, and patient clinical history information will be recorded in robust relational databases. We will conduct rigorous data quality assurance and quality control measures, and standardized longitudinal follow-up of all consented patients with materials in the pancreatic cancer biospecimen repository. The Core will also provide SPORE investigators with expert histopathological evaluation of tumor samples, as well as assistance in performing and interpreting immunohistochemical assays, selecting tissue for microdissection for downstream analysis, constructing tissue microarrays, and facilitating patient-derived organoid creation. The specific aims of the core are to (1) maintain and expand the collection, annotation, and storage of biospecimens for pancreatic cancer research, (2) perform systematic pathologic evaluation of all relevant ductal pancreatic adenocarcinoma samples and to prepare appropriate biospecimens for use by SPORE investigators, and (3) provide systematic microscopic assessment of response to therapy. Given the significant heterogeneity of pancreatic cancers, each of these aims requires expertise beyond what existing resources can provide, underscoring the need for this Core. All of the research projects will rely extensively on the Biospecimen Core to achieve their translational research objectives.