Promoting Physical Activity after Colorectal Cancer

描述（由申请人提供）：结直肠癌是美国第三大常见癌症，如果早期发现，预后良好。结直肠癌幸存者面临许多身体和心理社会后遗症，包括第二次癌症，对主要器官，认知和性功能的不良影响，工作和社会角色问题以及生活质量下降。辅助治疗（化疗和/或放疗）后，这些个体可能会增加心血管疾病、肥胖、骨质疏松症和未来癌症的风险。越来越多的证据表明，中等强度的体育活动可以改善身体功能，减少疲劳，增强活力，提高乳腺癌治疗者的身体自尊。结直肠癌幸存者报告增加疲劳，活力低下，身体功能受损和身体自尊障碍。然而，这一群体的研究相对不足，增加体力活动对他们恢复的潜在好处尚未得到研究。这项研究的重点是通过为已经完成结肠直肠癌治疗的患者提供以家庭为基础的体育活动计划来促进康复。该计划是基于我们之前在乳腺癌幸存者中的工作，包括三个多月的电话提供的身体活动咨询。心理咨询的理论基础是跨理论模型、社会认知理论和动机性访谈的要素。本研究将采用随机对照设计，在过去2年内完成结直肠癌治疗的134例患者中测试体力活动干预的有效性。结果将包括参与者在基线、3个月（治疗后）、6个月和12个月时的身体活动行为、健身、活力、疲劳、身体功能和身体自尊。我们还将跟踪干预成本，并对变化的调节者和介导者进行探索性分析，以帮助指导体育活动干预的未来发展，以促进结直肠癌的康复。

DESCRIPTION (provided by applicant): Colorectal cancer is the third most common cancer in the U.S. and if detected early, has a favorable prognosis. Colorectal cancer survivors face many physical and psychosocial sequelae including second cancers, adverse effects on major organs, cognitive, and sexual function, problems in work and social roles and reduced quality of life. Following adjuvant treatments (chemotherapy and/or radiation), these individuals may be at increased risk for cardiovascular disease, obesity, osteoporosis, and future cancers. There is growing evidence that moderate-intensity physical activity can improve physical functioning, reduce fatigue, enhance vigor and improve body esteem among those treated for breast cancer. Colorectal cancer survivors report increased fatigue, low vigor, impaired physical functioning and disturbances in body esteem. However, the group is relatively understudied and the potential benefits of increased physical activity to their recovery have not been examined. This study focuses on enhancing recovery by offering a home-based physical activity program to patients who have completed treatment for colorectal cancer. The program, based on our prior work among breast cancer survivors, consists of telephone--delivered physical activity counseling over three months. The counseling is based on the Transtheoretical Model, Social Cognitive Theory and elements of Motivational Interviewing. This study will test the efficacy of the physical activity intervention using a randomized controlled design among 134 patients who have completed treatment for colorectal cancer in the past 2 years. Outcomes will include physical activity behavior, fitness, vigor, fatigue, physical functioning, and body esteem among participants at baseline, 3 (post treatment), 6 and 12 months. We will also track intervention costs and conduct exploratory analyses of moderators and mediators of change to help guide the future development of physical activity interventions to enhance recovery from colorectal cancer.