Community-Level Influences on the Onset, Progression and Desistance of Adolescent

描述（申请人提供）：候选人Jasmina Burdzovic Andreas博士正在寻求5年的支持，通过指导职业发展奖（K 01），以（1）提高她对青少年药物使用和滥用的理解，（二）发展和扩大关于青少年药物使用障碍病因学和流行病学相关风险和保护因素的独立纵向研究人口，并（3）获得额外的专业知识，在生物统计学和流行病学适用于精神疾病的研究。该奖项将为候选人提供必要的培训，指导和研究时间，以便成功过渡到流行病学和人口心理健康的新领域，并掌握相关的研究方法。Burdzovic Andreas博士的目标是增加她在发展精神病理学方面的现有培训和她的纵向数据方法学经验，包括对青少年高危人群研究的流行病学方法，主要关注物质使用和滥用问题。因此，拟议的K 01将允许Burdzovic Andreas博士充分整合她在发展精神病理学方面的背景。她现有的统计知识，以及她对风险和弹性过程的持续研究兴趣，她的长期职业目标是成为一名独立调查员，关注青少年物质使用问题的流行病学和病因学。候选人将有效地利用她的家庭机构部门（布朗大学，社区卫生部）及其多个研究中心的跨学科性质。她将与全国公认的专家团队密切合作-包括博士斯蒂芬布卡（主要导师）和博士约瑟夫霍根，克里斯蒂娜杰克逊，和罗纳德塞弗（共同导师）-谁将支持她在她的培训，研究和职业发展目标。这些目标将通过以下方式实现：（1）在物质使用和滥用研究方面提供更多培训，（2）发展关于青少年物质使用的独立研究路线，其中包括确定和审查与自然发生的戒断和停止使用物质有关的社区一级因素（即，烟草，酒精和大麻）的青少年谁曾从事这些行为，（3）收购先进的生物统计学，纵向和流行病学研究方法的进一步专业知识。拟议的研究部分将利用来自两个现有纵向和社区代表性数据集的青少年数据：（1）斯普林菲尔德儿童发展项目（SCDP，N = 357;年龄范围：12-18）和（2）芝加哥社区人类发展项目（PHDCN，N = 2,976;年龄范围：9-24）。这两个数据集合在一起将有助于审查青少年药物使用和滥用的不同纵向概况，并查明与这些问题自然减少有关的更广泛的生态因素的独特组合-最终为预防和治疗工作提供信息。

DESCRIPTION (provided by applicant): The candidate, Dr. Jasmina Burdzovic Andreas, is seeking 5 years of support though the Mentored Career Development Award (K01) in order to (1) advance her understanding of adolescent substance use and abuse, (2) develop and expand an independent line of longitudinal research on risk and protective factors pertinent to etiology and epidemiology of substance use disorders among adolescent populations, and to (3) gain additional expertise in biostatistics and epidemiology as applied to the study of psychiatric disorders. The proposed award will provide the candidate with the training, mentoring, and research time necessary for the successful transition into the new fields of epidemiology and population mental health, and for the mastery of the relevant research methods. Specifically, Dr. Burdzovic Andreas aims to augment her existing training in developmental psychopathology and her methodologipal experience with longitudinal data to include epidemiologic approaches to the study of adolescent populations at risk, focusing primarily on substance use and abuse issues. Thus, the proposed K01 will allow Dr. Burdzovic Andreas to fully integrate her background in developmental psychopathology. Her existing statistical knowledge, and her continued research interest in the processes of risk and resilience with her long-term career goals of becoming an independent investigator concerned with epidemiology and etiology of adolescent substance use problems. The candidate will effectively take advantage of the interdisciplinary nature of her home institution department (Brown University, Department of Community Health) and its multiple research centers. She will work closely with a team of nationally recognized experts -- including Dr. Stephen Buka (primary mentor) and Drs. Joseph Hogan, Kristina Jackson, and Ronald Seifer (co-mentors) - who will support her in her training, research, and career development objectives. These objectives will be achieved though (1) additional training in substance use and misuse research, (2) the development of an independent line of research on adolescent substance use, which includes identifying and examining community-level factors associated with naturally-occurring desistence and cessation in substance use (i.e., tobacco, alcohol, and marijuana) among adolescents who had previously engaged in such behaviors, and (3) acquisition of further expertise in advanced biostatistics, longitudinal and epidemiologic research methods. The proposed research component will utilize data on adolescents from two existing longitudinal and community-representative data sets: (1) Springfield Child Development Project (SCDP, N = 357; Age range: 12-18) and (2) Project on Human Development in Chicago Neighborhoods (PHDCN, N = 2,976; Age range: 9-24). Together, these two data sets will allow for examination of different longitudinal profiles of adolescent substance use and abuse, as well as of identification of unique constellations of broader ecological factors associated with naturally occurring reductions in these problems - ultimately informing prevention and treatment efforts.