CRH dysregulation of brainstem autonomic circuits increases SUDEP risk

项目摘要 该多样性补充将支持伊曼纽尔科尔曼进一步他的技术和职业发展 准备申请博士学位的培训神经科学的程序。根据他以前的研究经验 调查早期生活压力的行为后遗症和他对神经系统疾病的兴趣，他将进行 与家长补助金有关但不重叠的研究，旨在调查长期压力的影响 癫痫的治疗效果曼尼的项目将调查早期生活压力对癫痫结果的影响， 加强母应用程序的总体目标，同时为Manny提供独立的研究 经验和职业发展培训。该项目还将研究早期生活压力是否会改变 慢性癫痫的海马内红藻氨酸模型中自发性复发性癫痫发作的频率。他将 评估早期生活压力是否会增加癫痫和/或SUDEP精神共病的易感性 风险他将获得体内电生理方法，手术技术和行为方面的培训。 评估。此外，他将参加实验室会议，期刊俱乐部，部门研讨会， 参加职业发展培训，同时在生物医学科学计划的建设多样性。在 此外，父母补助金涉及与UTHSA的Carie Boychuk博士实验室的合作。在这种多样性下 补充，曼尼将有机会参观博士Boychuk的实验室，并获得有关的知识， 自主神经系统的调节和压力对该系统的影响（见所附信件）。这 是一个技术上可行和概念上创新的项目，将扩大曼尼的技术技能， 为他的研究生生涯做好准备。

PROJECT SUMMARY This Diversity Supplement will support Emanuel Coleman to further his technical and career development training to prepare to apply for a Ph.D. program in Neuroscience. Building on his previous research experience investigating the behavioral sequelae of early life stress and his interest in neurological disorders, he will conduct research related, but not overlapping with the parent grant which seeks to investigate the impact of chronic stress on epilepsy outcomes. Manny’s project will investigate the impact of early life stress on epilepsy outcomes, strengthening the overall goals of the parent application while providing Manny with an independent research experience and career development training. This project will also examine whether early life stress alters the frequency of spontaneous recurrent seizures in the intrahippocampal kainate model of chronic epilepsy. He will evaluate whether early life stress increases vulnerability to psychiatric comorbities in epilepsy and/or SUDEP risk. He will gain training in in vivo electrophysiological methods, surgical techniques, and behavioral assessments. In addition, he will participate in lab meetings, journal clubs, Departmental seminars, and participate in career development training alongside the Building Diversity in Biomedical Sciences program. In addition, the parent grant involves a collaboration with Dr. Carie Boychuk’s lab at UTHSA. Under this Diversity Supplement, Manny will have the opportunity to visit Dr. Boychuk’s lab and gain knowledge regarding the regulation of the autonomic nervous system and the impact of stress on this system (see letter attached). This is a technically feasible and conceptually innovative project which will expand Manny’s technical skills and prepare him for the next steps in his graduate career.