MESA TASK AREA A - CORE STUDY OPERATIONS FIELD CENTER (FC).

动脉粥样硬化的多种族研究(MESA)是关于动脉粥样硬化的相关因素、预测因素和进展的研究。 45-84岁男女不同人群样本中的亚临床心血管疾病(CVD) 在基线时没有临床心血管疾病的证据。在MESA的初始供资期间，6814名参与者 在2000-2002年间从6个现场中心招募，并检查亚临床冠状动脉的证据 动脉粥样硬化，使用计算机断层扫描，心脏核磁共振，颈动脉超声，血流介导的臂动脉 扩张术、桡动脉眼压测量、踝臂指数测量和视网膜摄影。一批 其他变量包括腹主动脉CT、颈动脉MRI、心脏MRI标记以测量局部 心肌功能；已确定的和假定的实验室风险标记物；社会经济、心理 行为和环境特征；在台地的亚组中评估了遗传变异 一群人。对选定部件的检查在随后的五次检查中重复进行 大约16年，队列一直在跟踪临床心血管事件，自 基线检查。 这项建议是为了响应NHLBI RFP(编号75N92018R0078，多种族研究)而写的 动脉粥样硬化-田野中心)，寻求继续对MESA参与者进行随访和检查 努力实现以下科学目标：1)增强统计能力，分析 临床结果的预测因素，特别是在信息丰富的亚组中；2)研究亚临床到 临床心血管疾病；以及3)确定新的危险因素或导致疾病的因素之间的相互作用 病理生理学。此外，还将实现以下业务目标：1)继续队列后续行动 和信息收集，以记录临床事件；2)继续促进科学合作；3) 对MESA参与者进行有限的临床检查，作为辅助研究检查的平台 组件。 这项研究将继续支持在NHLBI合同之外资助的深入辅助研究。 这些研究将在业务上整合到主要研究中，数据将在整个 根据当前MESA和NIH的数据共享政策，研究的“MESA套件”。该研究的数据将提供给 感兴趣的调查人员通过定义的流程鼓励最大限度地提高数据利用率，同时保护 参与者保密。

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. This proposal is written in response to the NHLBI RFP (No. 75N92018R0078, Multi-Ethnic Study of Atherosclerosis – Field Center) that seeks to continue the follow-up and examination of the MESA participants in an effort to address the following scientific objectives: 1) enhance statistical power to perform analyses of predictors of clinical outcomes, particularly in informative subgroups; 2) study the progression of subclinical to clinical CVD; and 3) identify new risk factors or interactions among factors that inform disease pathophysiology. In addition, the following operational goals will be addressed: 1) continue cohort follow-up and information collection to document clinical events; 2) continue to foster scientific collaborations; and 3) conduct a limited clinical examination of the MESA participants as a platform for ancillary study examination components. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality.