RFA-GH-23-003, THAI-GER: THAIland Genomic surveillance of Emerging infectious diseases facilitating Rapid response

摘要/项目摘要： 新发传染病(EID)和再发传染病(REID)可以 在免疫幼稚的人群中迅速传播，引发流行病或大流行。 抗菌素耐药性(AMR)是导致大量死亡的另一个公共卫生问题 和经济损失。泰国与政府有关的传染病实验室是 以一种集中的方式组织，由社区医院首先收集样本 然后转移到区域和中心实验室进行测试和分析。虽然这件事 这种方法在管理季节性疾病和小规模流行病方面是有效的，它可能会导致 在较大暴发期间检测和控制疾病。除了具体和敏感 基于实验室的工具来管理EID，社区需要可现场部署的简单技术 可用于宰牲节监控。监测系统在监测和监测方面发挥着关键作用 预测传染病的爆发。为了增强监控能力，有必要 开发简单但高灵敏度和特异性的实验室工具，可以识别EID，Reids 以及中央和地方实验室的抗菌素耐药性，包括 生物信息管道、微生物基因组数据库和实验室管理系统。这个 基因分析平台的开发将有助于促进病原体基因组的分析， 尤其是在处理大量数据时。着力提升政府执政能力 机构和当地社区检测、监测和监视EID(呼吸道病毒、 虫媒病毒、细菌性传播感染和医院内细菌病原体)和AMR，我们建议 开发协调的、多层次的工具和系统。这些工具和系统将促进 对EID的早期发现和快速反应

Abstract/Project summary: Emerging infectious diseases (EIDs) and re-emerging infectious diseases (REIDs) can spread quickly among immunologically naïve populations, triggering epidemics or pandemics. Antimicrobial resistance (AMR) is another public health issue responsible for numerous fatalities and economic losses. The government-associated infectious disease laboratories in Thailand are structured in a centralized manner whereby samples are first collected by community hospitals and then transferred to regional and central laboratories for testing and analysis. While this approach is effective in managing seasonal diseases and small epidemics, it can cause delays in detecting and controlling diseases during larger outbreaks. Apart from specific and sensitive laboratory-based tools to manage EIDs, communities need field-deployable, simple technologies which can be used for EID surveillance. Surveillance systems play a critical role in monitoring and predicting outbreaks of infectious diseases. To enhance surveillance capabilities, it is necessary to develop simple but high sensitivity and specificity laboratory tools that can identify EIDs, REIDs and antimicrobial resistance capabilities in both central and local laboratories, including bioinformatic pipelines, microbial genomic databases, and laboratory management systems. The development of genetic analysis platforms will help facilitate the analysis of pathogen genomes, particularly when dealing with a large volume of data. To enhance the ability of government agencies and local communities to detect, monitor, and surveillance EIDs (respiratory viruses, arboviruses, bacterial STIs, and nosocomial bacterial pathogens) and AMR, we propose the development of coordinated, multi-level tools and systems. These tools and systems will facilitate early detection and rapid response to EIDs