MATHEMATICAL MODELING OF BIOLOGICAL NETWORK GOVERNING C ELEGANS VULVAL INDUCTI

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 C.线虫外阴发育是具有广泛实验数据的动物器官发生的范例。在外阴诱导过程中，六个多能外阴前体细胞（VPC）中的每一个都有三种命运（1 <$，2 <$，3 <$）。精确的1？-2磅-3磅VPC命运的形成受细胞间信号传导、细胞内信号转导和转录调节的网络控制。该网络的数学模型的构建将使假设生成，生物机制发现和系统行为分析成为可能。可以开发数学模型来对支配VPC 1-2-3模式形成过程的生物网络进行建模。我们提出了应用动态贝叶斯网络来建模网络组件之间的因果关系。该问题是计算密集型的，我们还建议实现并行算法，以加快计算。数学建模的实现将在C/C++和MPI。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. C. elegans vulval development is a paradigmatic example of animal organogenesis with extensive experimental data. During vulval induction, each of the six multipotent vulval precursor cells (VPCs) commits to one of three fates (1¿, 2¿, 3¿). The precise 1¿-2¿-3¿ formation of VPC fates is controlled by a network of intercellular signaling, intracellular signal transduction, and transcriptional regulation. The construction of mathematical models for this network will enable hypothesis generation, biological mechanism discovery, and system behavior analysis. A mathematical model can be developed to model the biological network that governs the VPC 1¿-2¿-3¿ pattern formation process. We proposed to apply dynamic Bayesian network to model the causal relationship among network components. The problem is computationally intensive, we also propose to implement parallel algorithm to speed up the computation. The implementation of the mathematical modeling will be in C/C++ and MPI.