SPECTROSCOPIC DIAGNOSIS OF ATHEROSCLEROSIS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 低密度脂蛋白（LDL）、氧化LDL和蛋白聚糖（如多功能蛋白聚糖）的蛋白质组分含有色氨酸，色氨酸是一种在308 nm激发波长下具有特征荧光特征的氨基酸。我们假设，在308 nm激发波长IFS 380，一种适合于临床使用的方法，内源性荧光光谱可以识别冠状动脉病变与浅表泡沫细胞（SFC）和/或蛋白聚糖。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The protein components of low-density lipoprotein (LDL), oxidized LDL and proteoglycans such as versican contain tryptophan, an amino acid with characteristic fluorescence features at 308 nm excitation wavelength. We hypothesize that intrinsic fluorescence spectroscopy at 308 nm excitation wavelength IFS380, a method suitable for clinical use, can identify coronary artery lesions with superficial foam cells (SFCs) and/or proteoglycans.