Development of an interference electroporation device to improve targeted cell pe
Development of an interference electroporation device to improve targeted cell pe
开发干扰电穿孔装置以提高靶向细胞性能
批准号：
8780288
负责人：
Richard Jason Connolly
金额：
$16.27万
依托单位：
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-09-18 至 2016-09-17
关键词：
AddressAdverse effectsAlgorithmsAnimalsAntineoplastic AgentsBiological ProductsCancer PatientCancerousCellsCessation of lifeClinicalClinical ResearchClinical TreatmentClinical TrialsComputer SimulationComputer softwareDevelopmentDevicesDiseaseDisseminated Malignant NeoplasmEffectivenessElectroporationEnsureEquationFrequenciesFutureGenesImmunotherapyMedicalMethodsModelingOperative Surgical ProceduresOutcomePhaseQuality of lifeReportingResearchSignal TransductionSkin CancerSolid NeoplasmSolutionsStagingTechniquesTechnologyTestingTherapeutic AgentsTimeToxic effectTransfectionWorkalternative treatmentbasecancer cellcancer therapychemotherapydesignelectric fieldimprovedin vivoinstrumentinstrumentationmathematical analysismelanomamodel developmentneoplastic cellnovelnovel strategiesplasmid DNAproduct developmentprogramsprototypepublic health relevanceresearch studysimulationtreatment planningtumoruptake
中文摘要
翻译
描述（由申请人提供）：在此，我们寻求开发用于癌性实体瘤的临床治疗的更有效和靶向的电穿孔装置。在临床环境中使用电穿孔将治疗剂导入肿瘤细胞中的应用是一种令人兴奋的癌症靶向治疗方法。挑战在于
工作是进一步开发一种临床电穿孔装置，该装置将利用波干涉现象产生靶向电穿孔波形以增加转染的有效性。
英文摘要
DESCRIPTION (provided by applicant): Here we seek to develop a more effective and targeted electroporation device for the clinical treatment of cancerous solid tumors. The application of using electroporation to transfect therapeutic agents into a tumor cells in the clinician setting is an exciting approach to a targeted treatment of cancer. The challenge for this
work is to further develop a clinical electroporation device that will use the phenomenon of wave interference to produce a targeted electroporation waveform to increase the effectiveness of transfection.
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