Neurobiology of relaxin-3/RXFP3 systems: anatomical and functional studies in transgenic mice

精神疾病是世界范围内的经济和健康负担，医疗支出费用巨大，生产力下降，患者生活质量差，死亡率高。松弛素-3是一种在神经回路中广泛发挥作用的肽，可以调节大脑活动，从而改变焦虑和情绪/睡眠障碍等情况。我们的研究评估了基因去除松弛素-3信号对行为的影响，这将增加我们对大脑功能的了解，并改善心理健康状况。

Mental illness is an economic and health burden worldwide, with huge costs in medical spending, lost productivity, poor quality of life for sufferers and mortality. Relaxin-3 is a peptide that acts widely within neural circuits to modulate brain activity that is altered in conditions such as anxiety and mood/sleep disorders. Our research assessing the effect of genetic removal of relaxin-3 signaling on behaviour will add to our knowledge of brain function and improve mental health outcomes.