Administrative Core

项目摘要/摘要--行政核心 行政核心(AC)将为弗吉尼亚联邦大学提供组织基础设施- 梅西癌症中心差异相关患者来源的异种移植开发和试验中心(VCU/MCC- D-PDTC)。通过我们的集体努力，VCU/MCC-D-PDTC以下称为卫生公平联盟 -Living PDX计划(U4HELPP)将获得和开发患者来源的异种移植物(PDX)和有机类化合物 (PDO)主要来自胰腺癌、乳腺癌、 泌尿生殖系统(GU)、妇科(GYN)、肺癌以及原发和晚期胃肠道恶性肿瘤。这个 U4HELPP利用VCU Massey癌症中心和VCU Health的领导地位和基础设施， 是一个为英联邦代表不足的少数族裔癌症患者提供服务的安全网医疗保健系统 弗吉尼亚。我们的团队也将利用我们互补的专业知识、研究兴趣和技术 作为我们的PDX/PDO专业知识的集体广度，以促进最大限度的项目协同效应和生产力。交流电 将与一个咨询委员会互动，该委员会包括临床肿瘤学、PDX领域的强大领导者 发展、差异研究、癌症预防和患者权益。通过与NCI的互动， 咨询委员会将为项目提供指导和监督，以确保整个研究及时取得进展。 总体而言，咨询委员会将提供强有力的组织监督，以开发与差异相关的PDX(D-PDX)模型 将在我们的机构内部使用，支持U4HELPP研究项目和核心，与内部共享 和PDX Net合作者，并提供给NCI患者衍生模型存储库(PDMR)。

PROJECT SUMMARY / ABSTRACT – ADMINISTRATIVE CORE The Administrative Core (AC) will provide organizational infrastructure for Virginia Commonwealth University - Massey Cancer Center Disparity-relevant Patient-Derived Xenograft Development and Trial Center (VCU/MCC- D-PDTC). Through our collective efforts the VCU/MCC-D-PDTC known hereafter as United for Health Equity - Living PDX Program (U4HELPP) will obtain and develop patient-derived xenografts (PDX) and organoids (PDO) primarily from underrepresented minority tumor samples from cancers of the pancreas, breast, genitourinary (GU), gynecologic (GYN), lung and primary and advanced gastrointestinal tract malignancies. The U4HELPP leverages the leadership and infrastructure of the VCU Massey Cancer Center and VCU Health which is a safety net health care system serving underrepresented minority cancer patients in the Commonwealth of Virginia. Our team will capitalize on our complementary expertise, research interests, and technologies, as well as our collective breadth of PDX/PDO expertise, to promote maximum project synergy and productivity. The AC will interact with an Advisory Board that includes strong leaders in the fields of clinical oncology, PDX development, disparities research, cancer prevention, and patient advocates. Through interactions with the NCI, the AC will provide direction and oversight of the project to ensure timely progress on the entirety of the studies. Overall, the AC will provide strong organizational oversight to develop disparity-relevant PDX (D-PDX) models that will be used within our institution supporting U4HELPP Research Projects and Cores, shared with internal and PDX Net collaborators, and provided to the NCI Patient-Derived Models Repository (PDMR).