UCLA Clinical Translational Science Institute

总结/摘要 加州大学洛杉矶分校临床和转化科学研究所是加州大学的一个研究伙伴关系 洛杉矶，雪松西奈医疗中心，查尔斯R。德鲁医学和科学大学 Harbor-UCLA医学中心/ Lundquist生物医学创新研究所。我们的使命是将生物医学 创新，以承担最大的健康需求的洛杉矶，一个种族和经济多元化 人口超过一千万的大都会。在过去的10年里，我们建立了一个强大的研究基础设施 来支持我们的使命我们与社会各界携手合作， 可预防的残疾和死亡的主要原因。支持这些进步的是简化的监管 基础设施演进我们已经建立了科学的审查，减少了42%的学习激活时间， 100%遵守ClinicalTrials.gov。随着我们进入下一个十年， 加强与我们的机构中心合作伙伴的整合，并扩大社区合作 以及卫生专业以外的调查人员。公平、多样性和包容性（EDI） 我们的CTSI的基本原则，我们已经开始了一个包容性的科学倡议，由我们的EDI高级领导 副主任，以确保我们的研究和培训计划继续接受这一指导 原则通过新的T1-T4研讨会和团队科学培训和机会，我们正在装备我们的 学员进行跨翻译谱多学科团队科学。我们正在系统 评估我们的CTSI成果和整体影响。加州大学洛杉矶分校CTSI有五个具体目标：1）提高 教育和培训，以准备和扩大翻译队伍，2）让利益相关者参与 社区在多学科团队科学和传播成功的合作模式，3） 将特殊人群（包括那些经历健康差异的人群）纳入翻译 研究，4）改进方法和流程，以加快高效，高质量，多地点的研究， 5）提供信息学解决方案，以推进高影响力的转化科学。

SUMMARY/ABSTRACT The UCLA Clinical and Translational Science Institute is a research partnership of the University of California Los Angeles, Cedars-Sinai Medical Center, Charles R. Drew University of Medicine and Science and the Harbor-UCLA Medical Center/ Lundquist Institute for Biomedical Innovation. Our mission is to bring biomedical innovations to bear on the greatest health needs of Los Angeles, an ethnically and economically diverse metropolis of more than 10 million people. In the past 10 years, we have built a robust research infrastructure to support our mission. In partnership with the community, we have made important advances against the leading causes of preventable disability and death. Supporting these advances is a streamlined regulatory infrastructure. We have instituted scientific review, reduced time-to-study-activation by 42%, and achieved 100% compliance with ClinicalTrials.Gov. As we enter our next decade, we are building on our progress by augmenting the integration with our institutional hub partners and broadening collaborations in the community as well as with investigators outside the health professions. Because Equity, Diversity and Inclusion (EDI) is a foundational principle of our CTSI, we have embarked on an Inclusive Science Initiative, led by our EDI Senior Associate Director, to ensure that our research and training programs continue to embrace this guiding principle. Through new T1-T4 seminars and team science trainings and opportunities, we are equipping our trainees to conduct multidisciplinary team science across the translational spectrum. We are systematically evaluating our CTSI outcomes and overall impact. The UCLA CTSI has five specific aims: 1) Enhance education and training to prepare and expand the translational workforce, 2) Engage stakeholder communities in multidisciplinary team science and disseminate successful models of collaboration, 3) Integrate special populations, including those experiencing health disparities, into translational research, 4) Improve methods and processes to accelerate efficient, high-quality, multisite research, and 5) Provide informatics solutions to advance high-impact translational science.