Clinical trials in womens cancers

2014年，我成为女性恶性肿瘤科的临床主任。我们目前正在分析07C0058临床试验的标本和数据-贝伐单抗和索拉非尼2期卵巢癌；贝伐单抗和达沙替尼的09-C-0019一期研究。2016年，我们发表了12C0191 - SMAC-mimetic biinapant 2期卵巢癌临床试验结果。研究09C0019 -贝伐单抗和达沙替尼1期试验接近累积，但有1例患者在随访中。血液采集研究14-C-0056结束；取而代之的是，我们打开17-C-0100收集NCI其他方案中癌症患者的血液和积液（胸膜和腹膜）。一项正在进行的治疗试验17-C-0011将测试用干扰素α和γ刺激的自体单核细胞进入卵巢癌妇女的腹腔的安全性。其他临床试验正在概念阶段开发中，或正在IRB审查中。在WMB内，我与Jung-min Lee和Stan Lipkowitz合作，担任其他几项临床试验的副研究员。

In 2014, I became the Clinical Director of the Women's Malignancies Branch. We are currently in the process of analyzing specimens and data from clinical trials 07C0058 - Bevacizumab and Sorafenib phase 2 in ovarian cancer; and 09-C-0019 phase 1 study of bevacizumab and dasatinib. In 2016 we published the results of clinical trial 12C0191 - SMAC-mimetic birinapant phase 2 in ovarian cancer. Study 09C0019 - Bevacizumab and Dasatinib phase 1 trial is closed to accrual but has 1 patient in follow up. A blood collection study 14-C-0056 closed; in its place, we opened 17-C-0100 to collect blood and effusions (pleural and peritoneal) from patients with cancer enrolled on other protocols at the NCI. An ongoing treatment trial, 17-C-0011, will test the safety of administering autologous monocytes stimulated with both interferon alpha and gamma into the peritoneal cavity of women with ovarian cancer. Additional clinical trials are under development at the concept stage or are under review by IRB. Within the WMB, I collaborate with Jung-min Lee and Stan Lipkowitz as Associate Investigator on several other clinical trials.