Neuronal copper homeostasis and the role of the Alzheimer Amyloid-Beta Precursor Protein (APP)

阿尔茨海默病（AD）正在给澳大利亚的医疗资源造成越来越大的负担。铜在阿尔茨海默病的发展中起着重要作用，旨在调节脑铜水平的药物正在进行阿尔茨海默病治疗试验，并显示出治疗效果。该项目将确定铜如何参与阿尔茨海默病，以便开发更有效的药物。重点将主要放在AD中心的铜结合蛋白上，并确定它们在AD发生和进展中的作用。

Alzheimer’s disease (AD) is creating a growing burden upon Australian medical resources. Copper plays an important role in the development of AD and drugs designed to adjust brain copper levels are being tested for AD treatment and show therapeutic benefits. This project will determine how copper is involved in AD so that more effective drugs can be developed. Focus will primarily be on copper-binding proteins central to AD and establishing their role in AD development and progression.