TOWARD THE DEVELOPMENT OF A PROTEIN: NON-PROTEIN MACROMOLECULAR ADJUVANTS.

开发新疫苗面临的一个现有问题是，需要针对发生在粘膜部位（如上呼吸道和胃肠道）的细菌感染。克服这一问题将需要使用新的疫苗配方和使用新的免疫增强剂（佐剂），以促进在粘膜部位有效的免疫反应。本研究将探索一种联合佐剂的添加性和潜在的协同活性，以特异性地诱导对一种新型亚单位疫苗的平衡免疫反应，这种疫苗旨在预防肠道病原体的感染。该项目将支持动物模型的配方活动和保护效果评估。

An existing problem being faced in the development of new vaccines is the need for targeting bacterial infections that occur at mucosal sites such as the upper airway and the gastrointestinal tract. Overcoming this problem will require the use of novel vaccine formulations and the use of novel immune enhancing agents (adjuvants) that promote immune responses that are effective at mucosal sites. This study will explore the additive and potentially synergistic activities of a combination adjuvant for their ability to specifically induce a balanced immune response to a novel subunit vaccine designed to prevent infection by an enteric pathogen. This project will support formulation activities and the evaluation of protective efficacy in an animal model.