Advancing Science for the Diagnosis and Treatment of Gastroparesis

摘要 胃轻瘫是一种以胃排空延迟为特征的胃功能障碍， 常伴有慢性恶心和呕吐、早饱、餐后 可能需要营养支持的饱腹感、腹痛和营养不良。这个 这项建议的广泛目标是提高我们对这种紊乱的理解，并 推进胃瘫及相关疾病的诊断和治疗。我们 建议通过三个具体目标实现这一目标，具体如下： 具体目标1：维护、扩展和完善胃瘫注册表，以便 能够对临床数据和生物样本进行关键的额外和新的分析。 具体目标2：在慢性阻塞性肺疾病患者中进行一项随机对照试验 胃轻瘫和功能性消化不良--餐后窘迫综合征。 具体目标3：进行一种潜在疾病改良的中试和可行性试验 胃轻瘫患者应用吡格列酮的探讨

Summary Gastroparesis is a disorder of gastric function characterized by delay in gastric emptying, frequently associated with chronic nausea and vomiting, early satiety, postprandial fullness, abdominal pain, and malnutrition that may require nutritional support. The broad objectives of this proposal is to improve our understanding of this disorder and advancing the diagnosis and treatment of gastroparesis and related disorders. We propose to do this through three specific aims, as follows: Specific Aim 1: To maintain, expand, and refine the Gastroparesis Registry in order to enable critical additional and new analyses of the clinical data and biosamples. Specific Aim 2: To conduct a randomized controlled trial of aprepitant in patients with gastroparesis and functional dyspepsia-postprandial distress syndrome. Specific Aim 3: To conduct a pilot and feasibility trial of a potential disease modifying approach using pioglitazone in patients with gastroparesis