New aminobenzimidazole antimalarial agents with a novel mechanism of action

疟疾是一种在全球造成重大负担和分布的疾病，包括在澳大利亚的北方邻国东帝汶、印度尼西亚和巴布亚新几内亚。在过去十年中，亚洲出现了对所有主要抗疟药物的耐药性，这意味着迫切需要具有独特作用机制的新抗疟药物。该项目旨在确定一类新的氨基苯并咪唑类抗疟药活性的新作用机制。

Malaria is a disease with a globally significant burden and distribution, including a presence in Australia’s northern neighbours East Timor, Indonesia and Papua New Guinea. Resistance to all major classes of antimalarial drugs has emerged in Asia in the last decade, meaning new antimalarials with unique mechanisms of action are urgently needed. This project seeks to identify the novel mechanism of action responsible for the activity of a new class of aminobenzimidazole antimalarials.