Oxidative Stress, Hormones and Women s Health

生物周期研究是一项前瞻性纵向队列研究，包括259名年龄在18至44岁之间的女性（98%的随访率），随访两个月经周期（2005-2007年）。这项研究旨在更好地了解月经周期功能以及生殖激素水平和氧化应激之间的复杂关系。自研究完成以来，在分析生物循环研究数据方面取得了很大进展。迄今已发表论文80余篇。生物循环研究为营养、环境和社会流行病学领域做出了重大贡献，为了解与绝经前妇女生殖和心脏代谢健康相关的各种因素提供了有价值的见解。特别是，已经评估了几种饮食因素与生殖激素和排卵的相关性，包括钠和锰等膳食矿物质（Kim et al. Br J Nutr 2018）。这些发现强调了饮食在生殖功能中的重要作用。评估潜在环境因素（包括双酚A、氯酚、二苯甲酮和对羟基苯甲酸酯）的进一步研究发现，酚类混合物与生殖激素的变化有关，这对生殖健康有潜在影响（Pollack等人，Environ Int 2018）。此外，还观察到卫生棉条的使用与汞水平和氧化应激生物标志物的升高有关，这表明卫生棉条可能是暴露于金属和化学物质的潜在来源，而这些金属和化学物质在很大程度上被忽视了（Singh等人，Environ Health 2018）。需要进一步研究驱动这些关联的机制，以了解对妇女健康的潜在影响。 总的来说，这项工作不仅在描述饮食和生活方式对激素功能的短期影响和月经周期功能障碍的标志物（例如，不排卵、黄体期不足和月经异常），但它们对慢性疾病风险的潜在长期影响。该团队打算在生物循环研究的现有研究结果的基础上，填补关键的研究空白，以回答育龄妇女的重要公共卫生问题。

The BioCycle Study was a prospective longitudinal cohort study comprising 259 women aged 18 to 44 years (98% follow-up rate) followed for two menstrual cycles (2005-2007). The study was designed to better understand menstrual cycle function and the intricate relationships between reproductive hormone levels and oxidative stress. Since completion of the study, much progress has been made in the analysis of the BioCycle Study data. To date, over 80 papers have been published. The BioCycle Study has contributed substantially to the fields of nutritional, environmental, and social epidemiology, offering valuable insights into various factors associated with premenopausal womens reproductive and cardio-metabolic health. In particular, several dietary factors have been evaluated with regard to their associations with reproductive hormones and ovulation, including dietary minerals such as sodium and manganese (Kim et al. Br J Nutr 2018). These findings have highlighted the important role of diet in reproductive function. Further research evaluating potential environmental factors, including bisphenol A, chlorophenols, benzophenones, and parabens, found that mixtures of phenols were associated with changes in reproductive hormones which has potential implications for reproductive health (Pollack et al. Environ Int 2018). In addition, it was also observed that tampon use was associated with elevation in mercury levels and oxidative stress biomarkers, indicating that tampons may be a potential source of exposure to metals and chemicals that have been largely ignored (Singh et al. Environ Health 2018). Further research into the mechanisms driving these associations is needed to understand the potential implications for women's health. Overall, this body of work has been influential in describing not only the short-term impact of diet and lifestyle on hormonal function and markers of menstrual cycle dysfunction (e.g., anovulation, luteal phase deficiency, and abnormal menses) but their potential long-term impact on chronic disease risk. The team intends to build upon its current findings from the BioCycle Study to fill critical research gaps in its quest to answer important public health questions for women of reproductive age.