West Virginia University Stroke COBRE

项目摘要/摘要 中风是导致美国人死亡的第五大原因，也是导致残疾的首要原因 开发有效的中风治疗方法仍然是当务之急。实验性中风 核心(ESC)是西弗吉尼亚大学(WVU)中风科布雷必不可少的核心 提供独特的专业知识，开发新的工具和中风动物模型，以增强 中风研究人员的有效性。ESC的总体目标是提供专业知识， 用于将卒中动物模型合并到 参加西弗吉尼亚大学卒中科考的初级调查人员和研究人员的研究 更大的西弗吉尼亚大学神经科学和心血管研究社区。四个建议的具体 ESC的目标将有助于将WVU Stroke Cobre提升为卓越中心， 从而，在Cobre资金结束后实现可持续发展。目标1：提供专业知识， 在啮齿动物模型中产生中风的仪器和资源。目标2：提供流程 用户可以通过它访问ESC的专业知识和资源。目标3：提供指导和 进行实验性中风研究的培训。目标4：开发新的动物模型并实施 实验性卒中核心的可持续性业务计划。实现这些具体目标将 为研究界提供一个高度运作的ESC，并为Cobre- 支持-ESC到独立的核心设施。

Project summary/Abstract Stroke is the fifth leading cause of death and the leading cause of disability among Americans and developing effective treatments for stroke remains a pressing need. The Experimental Stroke Core (ESC) is an essential core for the West Virginia University (WVU) Stroke CoBRE that provides unique expertise and develops novel tools and stroke animal models to enhance the effectiveness of stroke researchers. The overall goal for the ESC is to provide the expertise, training, instrumentation, and resources for the incorporation of animal models of stroke into the research of junior investigators participating in the WVU Stroke CoBRE and researchers in the greater WVU neuroscience and cardiovascular research community. The four proposed specific aims of the ESC will help advance the WVU Stroke CoBRE to a Center of Excellence and, thereby, achieve sustainability after CoBRE funding ends. Aim 1: To provide the expertise, instrumentation and resources to produce strokes in rodent models. Aim 2: To provide processes by which users can access the ESC expertise and resources. Aim 3: To provide mentoring and training in experimental stroke research. Aim 4: To develop new animal models and implement a sustainability business plan for the Experimental Stroke Core. Achieving these specific aims will provide a highly functioning ESC for the research community and bridge a transition of CoBRE- supported-ESC to an independent core facility.