Core D: Pharmacokinetics/Pharmacodynamics Core

摘要 药代动力学/药效学核心（核心D）将提供分析资源， 本申请中用于测量药物浓度和相关药物浓度的每个项目 各种样品类型中的生物标志物。这将主要通过使用质量 光谱方法，主要研究者具有重要的专业知识。方法 已经开发了用于检测药物和药物代谢物的铅（P2176）和 备用（P2114）化合物，并成功用于评估这些化合物的药代动力学 当药物被应用于呼吸道时。类似地，测量相关生物标志物的方法具有 并在初步实验中产生生物学上合理的结果。 此外，核心有能力在需要时添加新的生物标志物。

Abstract The Pharmacokinetics/Pharmacodynamics Core (Core D) will provide analytic resources to each of the Projects in this application to measure concentrations of drugs and relevant biomarkers within various sample types. This will primarily be accomplished using a mass spectrometric approach, with which the principal investigator has significant expertise. Methods to detect drug and drug metabolites have already been developed for both the lead (P2176) and backup (P2114) compounds and successfully utilized to assess the pharmacokinetics of these drugs when applied to the airways. Similarly, methods to measure relevant biomarkers have been developed and yield biologically plausible results in preliminary experiments. Furthermore, the Core has the capability of adding new biomarkers as the need arises.