Bioinformatics, Statistical and Methodological Core

翻译后摘要：生物信息学，统计和方法的核心 佛罗里达-加利福尼亚生物信息学、统计学和方法学（BSM）核心的主要目标 癌症研究，教育和参与（CaRE 2）健康公平中心将提供数据 管理、数据清理、数据存储以及将生成的所有信息发布到公共数据库 我们的中心。此外，还将为这三个国家提供生物信息学、统计学和方法学方面的支持。 癌症研究计划建议：1）线粒体肽组学和转录组学的差异， 前列腺癌（PC），2）增强吉西他滨纳米颗粒在胰腺PDX模型中的功效，和3） 种族差异对胰腺癌早期发展的贡献以及未来的项目 这将建立在他们的基础上，并传播给所有的CARE 2中心成员和整个科学界 及时的方式。我们将通过三个目标来实现这些目标。在第一个目标中，我们将与项目PI合作 优化数据管理的最佳实践，以满足这些项目的特定需求， 数据集。第一个目标是建立开发和维护中央数据、资源和样本的协议 管理系统，使多个学科之间的接口，包括基因组学，基础科学， 和临床医学。第二个目标是确保所有数据都是高质量的，符合良好的 实验室实践规范，并分发给所有的CaRE 2中心成员和科学 社区及时地。第三个目标是提供生物信息学、统计和 方法上的支持和教育机会，以照顾2中心。

Abstract: Bioinformatics, Statistical and Methodological Core The primary goal of the Bioinformatics, Statistical and Methodological (BSM) Core at the Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity Center is to provide the data management, data cleaning, data storage, and data release to public databases for all information generated by our center. In addition, it will provide bioinformatics, statistical and methodological support for the three cancer research projects proposed: 1) Disparities in Mitochondrial Peptidomics and Transcriptomics in Prostate Cancer (PC), 2) Enhancing Efficacy of Gemcitabine Nanoparticles in Pancreatic PDX Models, and 3) Contribution of Racial Disparity towards the Early Development of Pancreatic Cancer, as well as future projects that will build upon them, and disseminate to all CaRE2 center members and the scientific community at large in a timely fashion. We will reach these goals through three aims. In the first aim, we will work with project PIs to optimize best practices for data management for the specific needs of these projects and its highly unique datasets. This first aim establishes the protocols to develop and maintain a central data, resource and sample management system that enables interface between multiple disciplines including genomics, basic sciences, and clinical medicine. The second aim will be to ensure that all data are of high quality, conform to good laboratory practice specifications, and are disseminated to all CaRE2 Center members and the scientific community at large in a timely fashion. The third aim will be providing bioinformatics, statistical and methodological support and educational opportunities to the CaRE2 Center.