Core 1: Administrative Core

行政核心的目标将是协调科学、业务和财务方面的工作， 整个项目计划的实施。克雷格埃尔梅茨博士将领导行政核心， 将由各个项目的负责人和核心主任协助。内部 和外部咨询委员会将向行政核心提供关于 每个项目和科学核心的科学方向。行政核心将 提供必要的领导、监督、指导和行政支持服务 及时和合乎道德地开展与本计划项目相关的研究所必需的。在 此外，行政核心将减少项目和核心领导人和其他 人员需要花费在行政细节上，并允许他们专注于科学 方案的目标。核心还将促进 计划项目的组成部分。行政核心将通过 以下职责：1.规划、协调和执行 项目和核心，并保持项目和核心的良好财务管理。2.到 通过确保高质量和充分利用核心设施， 提供的服务，并评估所有项目和核心的资源分配情况。3.促进 项目和核心之间的有效互动，并促进沟通， 加强项目和核心科学家之间的思想交流。4.协调评价 内部和外部咨询委员会。5.为了与UAB的官员接触， 国家癌症研究所、威斯康星州大学和其他监管机构 以确保机构和NIH合规。协调委员会的定期会议， 数据安全监查委员会，并向IRB、NCI和其他各方提供报告， 这些报告应该传达给谁。行政核心将定期提供 向NCI报告临床生物标志物中所用试剂的有效性和毒性 审判6.协调核心的生物统计和生物信息学活动，以确保 调查人员可随时获得统计咨询和支持。

The goal of the Administrative Core will be to coordinate the scientific, operational, and financial operations of the entire Program Project. Dr. Craig Elmets will lead the Administrative Core and will be assisted by the leaders of the individual projects and by the core directors. The Internal and External Advisory Committees will offer additional advice to the Administrative Core on the scientific direction of each of the Projects and the Scientific Cores. The Administrative Core will provide the necessary leadership, oversight, direction, and administrative support services necessary for the timely and ethical conduction of research related to this Program Project. In addition, the Administrative Core will reduce the time Project and Core leaders and other personnel need to spend on administrative details, and allow them to concentrate on the scientific goals of the program. The Core also will facilitate interaction and communication between components of the Program Project. The Administrative Core will accomplish this with the following responsibilities: 1. To plan, coordinate and implement the administrative activities of the Projects and Cores, and to maintain sound fiscal management of the Projects and Cores. 2. To provide oversight to the core facilities by assuring high quality and adequate utilization of the services provided, and to evaluate resource allocation to all projects and cores. 3. To promote productive interactions between the Projects and Cores and to foster communication that will enhance the exchange of ideas between Project and Core scientists. 4. To coordinate evaluation by the Internal and External Advisory Committees. 5. To interface with officials at UAB, the National Cancer Institute, the University of Wisconsin subcontract and other regulatory agencies to ensure that there is Institutional and NIH Compliance. To coordinate regular meetings of the Data Safety Monitoring Board and provide their reports to the IRB, the NCI and other parties to whom these reports should be communicated. The Administrative Core will provide regular reports to the NCI on the efficacy and toxicity of the reagents employed in the clinical biomarker trial. 6. To coordinate biostatistical and bioinformatics activities of the core to ensure that investigators have ready access to statistical consultation and support.