PCTC Administrative Coordinating Center

摘要 为了满足NHLBI祖细胞翻译联盟(PCTC)对1)管理的需求 基础设施，以组织互动和促进PCTC调查人员之间的合作，2)监督 利用预留资金刺激合作研究和技能发展的计划，3) 在PCTC调查人员之间以及与研究人员之间及时共享PCTC生成的数据和试剂 社区，以及4)便利获得美国食品和药物管理局准备工作的专业知识 (FDA)IND和IDE应用，我们建议成立PCTC协调中心以响应RFA-HL-16-022， 工作人员具有在NHLBI祖细胞类似领域工作多年的经验 生物联盟(PCBC)行政协调中心(ACC)；他们在以下方面拥有丰富的经验 协调中心、组织和进行征集/审查/和授予研究或 技能发展，FDA准备IND和IDE应用程序的程序， 合作协议、联合体基础设施、网站、通信、监测和文件。 我们将调整和改进我们的基础设施(硬件、软件、网站和链接、办公室、办公室 设备和工作人员)，以便PCBC ACC延伸到PCTC，从而立即开始运行 在PCTC的第一天。我们将继续扩展现有基础设施的功能，以增加、 创新地使用社交媒体，覆盖PCTC社区的各个角落，并扩展到更广泛的研究领域 社区。我们将继续执行PCBC的技能发展支持程序，并支持 征求/审查/授予试点研究和辅助/合作研究，其中已有31项 辅助性/协作性研究奖和14个试点研究奖，分别来自200多项申请和26项 “JUMP START(小型博士后研究员试点研究)”奖项来自78个申请者。 我们的建议是高效和创新的，因为我们的专业知识和经验 调查人员，他们彼此备份的不可中断性质，以及 我们将从PCBC扩展和更新系统到PCTC。中国人民银行行政协调委员会能够完成所有 它做到了，只有不到3%的财团预算花在了研究中心、核心和他们的 项目。将资源引导到翻译研究，支持必要的基础研究 建立在PCBC基础设施基础上的翻译研究和技能开发 通过社交媒体扩展我们的基础设施将是实质性的。

Abstract To meet the need of the NHLBI Progenitor Cell Translational Consortium (PCTC) for 1)administrative infrastructure to organize interactions and facilitate collaborations between PCTC investigators, 2) oversight of programs of programs using set-aside funds to stimulate collaborative research and skills development, 3) timely sharing of PCTC-generated data and reagents among PCTC investigators and with the research community, and 4) for facilitated access to expertise for preparation of U.S. Food and Drug Administration (FDA) IND and IDE applications, we propose a PCTC Coordinating Center in response to RFA-HL-16-022, staffed by individuals who bring years of experience working along similar lines in the NHLBI Progenitor Cell Biology Consortium (PCBC) Administrative Coordinating Center (ACC); they have extensive experience in coordinating centers, organization and conduct of solicitation/review/ and award of proposals for research or skills development, FDA procedures for preparation of IND and IDE applications, collaborative research under cooperative agreements, consortium infrastructure, web site, communications, monitoring and documentation. We will adapt and advance our infrastructure (hardware, software, web sites and links, offices, office equipment and staff) in place for the PCBC ACC to extend to the PCTC resulting in an immediate, running start for the PCTC on day one. We will proceed to expand the functions of the extant infrastructure to additional, innovative use of social media to reach all corners of the PCTC community and out to the broader research community. We will continue the PCBC procedures for Skills Development support as well as support of solicitation/review/and award of pilot and ancillary/collaborative studies of which there have been 31 ancillary/collaborative study awards and 14 pilot study awards resulting from over 200 applications and 26 "jump start (small post-doctoral fellow pilot study)" awards from 78 applications. Our proposal is both highly efficient and innovative because of the expertise and experience of our investigators, the uninterruptable nature of their backup for each other and the uninterruptable nature of the systems we will extend and update from the PCBC to the PCTC. The PCBC ACC was able to accomplish all that it did with less than 3% of the consortium budget spent outside of the research hubs, cores and their projects. The channeling of resources to translational research, basic research necessary to support translational research and skills development that building on the PCBC infrastructure and the additional extension of our infrastructure through social media will be substantial.