Inflammatory and immune dysregulation associated lung disease

肺部受累的免疫或炎症调节障碍可从最初的表现，如结节病，或相对轻微的表现，如孟德尔易感分支杆菌病免疫缺陷。虽然这两者都可能与肺部的肉芽肿炎症有关，但临床上的肺部表现以及治疗策略都有很大的不同。慢性呼吸道感染实验室寻求利用与临床免疫学和微生物学实验室以及NIAID和NIAMS内其他分支机构的密切合作，重点研究这些疾病，以描述已知和新出现的免疫性和炎症性疾病的肺部表现。在过去的一年里，我们继续与北卡罗来纳大学的研究人员合作，以更好地确定STAT3在改变呼吸道清除中的作用。我们共同获得了床边资助，用于收集和分析呼吸道上皮细胞、支气管肺泡灌洗、痰和其他呼吸道标本和床边措施，以表征呼吸道清除机制和潜在缺陷。

The pulmonary involvement in disorders of immune or inflammatory regulation can range from a primary manifestation such as with sarcoidosis or a relatively minor manifestations such as seen with the Mendelian Susceptibility to Mycobacterial Disease immune deficiencies. While both of these can be associated with granulomatous inflammation in the lung, the clinical pulmonary manifestations are quite different as are the management strategies. The Laboratory of Chronic Airway Infection (LCAI) has sought to capitalize on the close collaboration with the Laboratory of Clinical Immunology and Microbiology and other branches within the NIAID and NIAMS focused on these disorders to describe the pulmonary manifestations of known and emerging immune and inflammatory diseases. Over the past year we have continued collaboration with investigators at the University of North Carolina to better define the role of STAT3 in altered airway clearance. We were jointly awarded a Bench-to-Bedside grant that has funded collection and analysis of airway epithelial cells, bronchoalveolar lavage, sputum, and other respiratory specimen and bedside measures for characterization of the airway clearance mechanisms and potential defects.