MEDICATION DISCOVERY USING RAT MODELS OF RELAPSE. PERIOD OF PERFORMANCE: 7/10/2019-7/9/2020. N01DA-19-8949

本合同的目的是确定新型化合物在使用可卡因、尼古丁、甲基苯丙胺或阿片类药物复发的动物模型中的体内疗效。这包括在训练有素的动物身上进行的下列试验（例如）：(1)测试化合物在一段时间的实验消失后阻止足震或其他应激源引起的反应恢复的能力；(2)被试化合物在一段时间消失后阻断或减少启动诱导的反应恢复的能力；(3)测试化合物阻断条件提示（先前与训练药物配对）在消失一段时间后恢复对训练药物反应的作用的能力。

The objective of this contract is to determine the in vivo efficacy of novel compounds in animal models of relapse using cocaine, nicotine, methamphetamine, or opioids. This includes the following tests in animals trained to self- administer cocaine (for example): (1) the ability of a test compound to block footshock or other stressor-induced reinstatement of responding after a period of experimental extinction; (2) the ability of a test compound to block or reduce priming-induced reinstatement of responding after a period of extinction; and (3) the ability of a test compound to block the effects of a conditioned cue (previously paired with the training drug) to reinstate responding for the training drug after a period of extinction.