Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging

爱因斯坦-内森休克中心(E-NSC)的研究开发核心利用资源 资助26项试点和可行性(P&F)研究，其中大部分授予初级调查人员或已建立 在衰老生物学方面寻求新研究方向的研究人员或对衰老陌生的研究人员。 其中，超过50%的获奖者表现出明显的成功结果，这表明收购 资金和/或提交手稿和新的赠款申请。鉴于这一成功，我们打算继续 我们的目标是将P&F资金作为RDC交付成果的一部分。这些P&F研究旨在 并将继续在爱因斯坦和成员机构加强和支持E-NSC科学。P&F基金 将优先分发给有功绩的初级调查人员或年迈的新手。第二个主要目标是 E-NSC一直在寻找有潜力过渡到老龄化研究的新教师，并提供 通过包括拨款申请过程在内的多个门户网站对他们进行持续指导。为此，我们 已经取得了很大的成功，因为我们吸引并建议了初级研究人员，他们申请和 成功地从NIH/NIA获得了资金。此外，爱因斯坦的几名新招聘的教职员工 将他们的主要关注点转移到衰老的基础生物学上。我们将继续吸纳老牌资深员工 爱因斯坦的研究人员将指导和支持研究人员准备P&F应用程序和新的 P&F奖获得者。区域发展委员会的第三个目标将是传达其重要的机会和可利用的 资源，其中包括P&F、核心服务以及对受训人员和知名调查人员的指导。这将是 通过各种平台，如衰老生物学课程，通过特邀讲座和研讨会，以及通过 互动社区活动，如爱因斯坦黑客马拉松和一年一度的E-NSC小型务虚会。我们相信 RDC的活动加强了E-NSC社区对老龄化研究的活跃，吸引了新的研究人员对老龄化- 开展相关研究，成功推动老龄相关领域的新研究。考虑老龄化问题 爱因斯坦领导层的一个关键优先事项，体现在机构承诺与预算的P&F相匹配 基金，每年为P&F赠款提供高达300,000美元的可用资金。这将允许为AT提供资金 任何一年至少有7-12个P&F项目。因此，在下一个资助期，我们将继续推动 已经取得成功的计划，并推出新的计划，主要目标是提高认识 衰老过程在生物学的各个方面无处不在。

The Research Development Core of the Einstein-Nathan Shock Center (E-NSC) has leveraged resources to fund 26 pilot and feasibility (P&F) studies, most of which were granted to junior investigators or established investigators pursuing novel research directions in the biology of aging or investigators who are new to aging. Of these, more than 50% of awardees demonstrated clear outcomes of success indicated by the acquisition of funds and/or submission of manuscripts and new grant applications. Given this success, we intend to continue with our objective to maintain P&F funding as part of the RDC deliverables. These P&F studies are designed to and will continue to enhance and support E-NSC science at Einstein and at member institutions. The P&F funds will be preferentially distributed to meritorious junior or ‘new to aging’ investigators. A second major objective of the E-NSC has been to identify new faculty who have the potential to transition to aging research and to provide continuous mentoring to them through multiple portals including the grant application process. To that end, we have had much success in that we have attracted and advised junior researchers who have applied for and successfully obtained funding from the NIH/NIA. Additionally, several newly recruited faculty to Einstein have shifted their primary focus to the basic biology of aging. We will continue to draw on established senior investigators at Einstein to mentor and support researchers in their preparation of P&F applications and new P&F awardees. The third objective of the RDC will be to communicate its important opportunities and available resources, which includes P&Fs, core services and mentoring to trainees and established investigators. This will occur through various platforms such as the Biology of Aging course, via invited talks and seminars, and through interactive community events such as the Einstein Hackathon and the annual E-NSC mini-retreats. We believe that RDC activities strengthen the E-NSC community active in aging research, attract new investigators to aging- related research, and successfully promote new research endeavors in aging-related areas. Aging is considered a key priority for the leadership at Einstein as shown by the Institutional commitment to match budgeted P&F funds, yielding up to $300,000 annually in total available funds for P&F grants. This will permit the funding of at least 7-12 P&F projects in any given year. Consequently, in the next funding period, we will continue to drive the programs that have been successful and introduce new programs with the primary objective of raising awareness about the omnipresence of the aging process in all aspects of biology.