Informatics Core

信息学核心项目摘要 天然产物（NP）-药物相互作用（NPDI）研究跨越几个学科，包括采购和 表征候选NP材料（分析核心），体外和临床评估NPDI的可能性 （药理学核心）和数据传播（信息学核心）。现有的NPDI卓越中心 研究（NaPDI中心），目前在其成功的第五年，由世界知名的专家在每一个 这些领域，并为NPDI研究提供领导。Informatics Core创建了一个基于云的数据 存储库，为手动NPDI研究数据输入和发布提供安全的工作流。仓库是一个 如何使NPDI数据可查找、可访问、可互操作和可重用（FAIR）的领先示例。很长的- 数据储存库的长期可持续性取决于其对相关利益攸关方的用处。信息学 此更新应用程序的核心组件提出了三个具体目标，这些目标可以细化数据存储库， 扩大NaPDI中心的信息能力。目标1：核心将向数据存储库添加功能， 增加其对不断增长的NPDI研究人员社区的有用性，包括R21伙伴受赠者。等 其功能包括基于简单易用的数据输入表单的简化的外部数据提交流程， 使用通用数据格式的Web服务。新的数据摘要和可视化将为研究人员提供 每种NP促进药代动力学NPDI潜力的完整循证概述。目标2： 药理学核心先前开发了一种高效和稳健的方法，称为支点模型，用于 * 选择和优先考虑作为NPD潜在促进因素的NPs。这种新模式的应用目前是一种 耗时的手动任务。信息学核心将通过开发信息学- 的方法，以加快收集和总结的数据需要应用支点模型，提供 自动化和持续评估高优先级NP中心和外部NP研究人员。核心 还将通过使用以下数据生成NP的药物警戒信号数据来创新NP的识别 毒物中心报告和两个FDA不良事件报告系统。这项新功能将为研究人员提供 对报告的不良事件类型和涉及NP的伴随暴露有重要见解。目的 3：信息学核心将扩大数据存储库的使用和效用， 和临床实践的利益相关者。为了在NPDI研究中吸引跨学科的科学家，我们 将扩大我们的营销策略。捕获考虑潜在NPDI的临床实践利益相关者， 药物订购和协调活动，我们将设计NPDI临床决策支持工件， 通过以用户为中心的方法提供服务，这种方法受到潜在药物决策支持方面的最新进展的启发， 药物相互作用这些目标的实现将导致一个学习NPDI研究系统，将改善 帮助患者避免NPDIs。

PROJECT SUMMARY OF THE INFORMATICS CORE Natural product (NP)-drug interaction (NPDI) research spans several disciplines that include sourcing and characterizing candidate NP materials (Analytical Core), in vitro and clinical assessment of NPDI liability (Pharmacology Core), and data dissemination (Informatics Core). The existing Center of Excellence for NPDI Research (NaPDI Center), currently in its fifth successful year, consists of world-renowned experts in each of these areas and provides leadership for NPDI research. The Informatics Core has created a cloud-based data repository that provides a secure workflow for manual NPDI study data entry and publishing. The repository is a leading example of how to make NPDI data findable, accessible, interoperable, and reusable (FAIR). The long- term sustainability of the data repository is dependent on its usefulness to relevant stakeholders. The Informatics Core component of this renewal application proposes three SPECIFIC AIMS that refine the data repository and expand the informatics power of the NaPDI Center. AIM 1: The Core will add features to the data repository to increase its usefulness for a growing community of NPDI researchers, including companion R21 grantees. Such features include a streamlined external data submission process based on simple-to-use data entry forms and web services that use a common data format. New data summaries and visualizations will provide researchers a complete evidence-based overview of each NP’s potential to precipitate pharmacokinetic NPDIs. AIM 2: The Pharmacology Core previously developed a highly effective and robust method, termed the fulcrum model, for selecting and prioritizing NPs as potential precipitants of NPDIs. Application of this novel model is currently a time-consuming manual task. The Informatics Core will innovate the fulcrum model by developing an informatics- based method to expedite the collection and summarization of data needed to apply the fulcrum model, providing an automated and continual appraisal of high priority NPs to the Center and external NP researchers. The Core will also innovate the identification of NPs by generating pharmacovigilance signal data for NPs using data from poison center reports and two FDA adverse event reporting systems. This new feature will provide researchers with important insight into the types of reported adverse events and concomitant exposures involving NPs. AIM 3: The Informatics Core will broaden the usage and utility of the data repository for both the research community and clinical practice stakeholders. To capture scientists across the spectrum of disciplines in NPDI research, we will expand our marketing strategy. To capture clinical practice stakeholders who consider potential NPDIs during medication ordering and reconciliation activities, we will design NPDI clinical decision support artifacts and services through a user-centered approach inspired by recent advances in decision support for potential drug- drug interactions. Accomplishment of these aims will result in a learning NPDI research system that will improve public health by helping patients avoid NPDIs.