Administrative Core: Cellular and molecular mediators of fibrosis in the development of urinary tract dysfunction

项目总结--行政核心 行政核心(核心A)的总体任务是协调和成功管理UW- 麦迪逊·奥布莱恩研究中心，包括波士顿大学和德克萨斯大学西南分校，领导良性泌尿学研究 通向未来。奥布莱恩良性泌尿外科研究中心的首要目标是确定 导致下尿路功能障碍(LUTD)从而导致良性前列腺增生症(BPH)的机制 相关下尿路症状(LUTS)。成功完成的标准由RFA 18-029定义 并包括开展和传播优秀的良性泌尿外科研究，提供急需的 为现场提供资源，并提供出色的教育丰富，同时促进下一代 良性泌尿科研究人员。该中心的目标是LUTD的新的和令人兴奋的机制，即前列腺纤维化 并将其转化为临床相关的治疗和生物标记物，用于患者分层。BPH/LUT可以是 威胁生命，影响生活质量，是一种代价高昂的疾病，NIDDK希望根除。核心A将实现 通过在首要的行政职责中提供杰出的领导力、远见和效率，实现这些目标。 核心A的组织结构和领导层包括两名公认的杰出调查人员和 在领导研究小组和培训计划中的互补能力。瑞克博士将继续担任核心职务 他是一名董事，将承担核心A的日常管理和监督的主要责任。 还负责获取和管理商机池并在内部维护广泛的互动 生物医学界。Vezina博士将担任Core A的副主任，并将指导教育 浓缩计划。核心A将与其外部顾问委员会(EAB)成员和内部顾问进行互动 董事会(IAB)每半年举行一次。中心的所有会员或相关会员将被邀请参加 中心活动包括研讨会、务虚会、商务会议和其他特殊活动。瑞克博士和 Vezina在NIDDK会议上会见NIDDK执行指导委员会(ESC)和外部专家小组(EEP) 年度反向现场访问(见推荐信，博士，ESC主席马克·尼尔森)。他们的领导力和经验 将使我们能够促进我们的中心项目、核心B以及其他中心(U54、P20、 K12)通过：沟通、协作和协调。进一步的互动和数据传播将 与NIDDK的奥布莱恩中心互动核心、NIDDK计划官员、美国 泌尿外科学会研究室、科学学会等场所。在NIDDK的指导下， 良性泌尿学研究社区有一个可行的焦点--奥布莱恩中心--在那里集中想法， 调研、资源、培训，提供共识，发出统一声音。奥布莱恩中心不仅仅是 各部分的总和，相反，它们提供领导，与研究人员协作，并为泌尿科提供 社区超越服务于自己的中心。核心A将领导这一NIDDK共同愿景。

PROJECT SUMMARY - ADMINISTRATIVE CORE The Administrative Core (Core A), has an overall mission to coordinate and successfully manage the UW- Madison O’Brien Research Center including UM-Boston and UT-Southwestern and lead benign urology research into the future. The overarching goal of the O’Brien Center for Benign Urology Research is to identify mechanisms that result in lower urinary tract dysfunction (LUTD) that result in benign prostatic hyperplasia (BPH) related lower urinary tract symptoms (LUTS). Criteria for successful completion are defined by the RFA 18-029 and include performing and disseminating outstanding benign urologic research, provide highly needed resources for the field, and provide outstanding educational enrichment while promoting the next generation of benign urology researchers. The Center targets new and exciting mechanisms of LUTD namely prostate fibrosis and translates it to clinically relevant therapeutics and biomarkers for patient stratification. BPH/LUTS can be life-threatening, affect quality of life, and is a costly disease, which NIDDK wants eradicate. Core A will achieve these goals by providing outstanding leadership, vision, and efficiency in the overarching administrative duties. The organization structure and leadership of Core A includes two outstanding investigators with recognized and complementary abilities in leading research groups and training programs. Dr. Ricke continues to serve as Core A director and will assume primary responsibility for day to day management and oversight of Core A. He will also be responsible for obtaining and managing the Opportunity Pool and maintain extensive interactions within the biomedical community. Dr. Vezina will serve as Associate Director for Core A and will direct the Educational Enrichment Program. Core A will interact with members of its external advisory board (EAB) and internal advisory board (IAB) on a semi-annual basis. All members or associated members of the center will be invited to partake in center functions including seminars, retreats, business meetings, and other special events. Drs. Ricke and Vezina meet with the NIDDK Executive Steering committee (ESC) and External Expert Panel (EEP) at NIDDK’s annual reverse site visit (see letter of reference Mark Nelson, PhD, ESC Chair). Their leadership and experience will allow us to promote interactions between our Center Projects, Core B, as well as other centers (U54, P20, K12) through: communication, collaboration, and coordination. Further interactions and data dissemination will occur in conjunction with the NIDDK’s O’Brien Center Interaction core, NIDDK program officials, American Urological Association Office of Research, scientific societies, and other venues. As directed by NIDDK, the benign urology research community has a viable focal point--The O’Brien Centers--in which to centralize ideas, research, resources, training, provide consensus, and offer a unified voice. The O’Brien Centers are more than the sum of parts, rather they provide leadership, synergize with researchers, and provide to the urology community above and beyond serving one’s own Center. Core A will lead this NIDDK shared vision.