Real Time Analysis of Diet and Activity Data

描述（由申请人提供）：我的职业发展目标是成为一名独立的研究人员，专门从事行为生活方式干预的统计方法的开发和应用。我是一名生物统计学家，在分析随机临床试验数据和开发处理缺失数据的方法方面有着丰富的经验。K07奖将以过去的经验为基础：(1)提供饮食和体育活动干预方面的培训，重点是评估、坚持和生活方式行为的决定因素；(2)提供指导指导，开发专门用于分析行为干预临床试验中收集的实时饮食和活动数据的统计方法。为了实现这些目标，我制定了一个全面的教育计划，包括由一名行为干预学家、一名专门研究行为干预的生物统计学家、一名研究体育活动评估的运动学家、一名营养流行病学家和一名分析加速度计输出的统计学家组成的专家导师。我提出的研究既加强了我的训练，又提供了原始的、创新的统计方法来回答有关行为干预的重要问题。研究计划的具体目标如下：1)建立统计模型，实时研究体育活动对饮食的影响。2)识别预测长期行为改变的因素。3)通过放宽关于缺失数据的假设，扩展目标1和目标2中的统计模型。这项职业发展奖的研究和培训将使我成为研究项目和拨款的首席研究员，开发统计方法来调查行为改变的机制，并改进对饮食和活动行为的评估。

DESCRIPTION (provided by applicant): My goal for this career development award is to become an independent researcher specializing in the development and application of statistical methods for behavioral lifestyle interventions. I am a biostatistician with significant experience analyzing data from randomized clinical trials and developing methods for handling missing data. This K07 award will build on this past experience by: (1) providing training in diet and physical activity interventions, focusing on assessment, adherence, and the determinants of lifestyle behaviors, and (2) providing mentored guidance to develop statistical methods specifically designed to analyze real-time diet and activity data that is gathered in clinical trials of behavioral interventions. To achieve these goals, I have developed a comprehensive educational plan, including expert mentors consisting of a behavioral interventionist, a biostatistician who specializes in behavioral interventions, a kinesiologist whose research expertise is in physical activity assessment, a nutritional epidemiologist, and a statistician who is an expert in the analysis of accelerometer output. The research I have proposed both reinforces my training and provides original, innovative statistical methodology to answer important questions regarding behavioral interventions. The research plan focuses on the following specific aims: 1) Develop statistical models to investigate the effects of physical activity on diet at the real-time level. 2) Identify the factors which are predictive of long-term behavior change. 3) Extend the statistical models in aims 1 and 2 by relaxing assumptions regarding missing data. The research and training in this career development award will prepare me to be a principal investigator on research projects and grants that develop statistical methodology to investigate mechanisms of behavior change and improve the assessment of diet and activity behaviors.