Nature-inspired Aqueous Biodegradable Adhesives for Abdominoplasty

项目摘要 浆液瘤是许多外科手术中最常见的不良反应，据估计有一半以上的患者会出现浆液瘤。 在所有腹部整形手术中。因为腹部成形术是最常见的美容手术之一 在美国(每年150,000人)，血清肿块的形成是一个主要问题。与浆液瘤有关的问题 累积包括患者不适、切口破裂和手术部位感染。这些问题导致了 增加不受欢迎的手术，减少美容效果，并显著增加医疗成本。 已经使用了各种策略来减少术后浆液瘤的发生，包括手术方法， 滑石粉滴注、封闭吸引管、固定化、纤维蛋白/凝血酶喷雾、压迫和硬化剂。全 这些方法中的一种试图通过促进破坏的组织平面的重新粘连来消除死亡空间。 目前可用的商用粘合剂包括纤维蛋白胶和生物聚合物，如BioGlue®/Tisseel®和 分别为TIsGlu®。这些产品在水环境中的性能很差，很弱 附着在湿组织上，降解时间短，肿胀率高得危险，和/或因有毒而产生细胞毒性 化学交联剂用于粘合。临床结果往往不令人满意，术后出现浆液性病变。 即使当当前的粘合剂被用作排水管的附件时，结垢也很常见。这样做的目的是 STTR第一阶段的提案是开发Aleo BME的专有超强弹性双相胶(BP Glue)。 用于预防腹部成形术后的血清肿胀。BP胶水的新奇之处在于 采用独特的黏附机制，结合了植物启发的生物黏附策略和粒子 借鉴水泥工业的填充理论开发含水仿生湿组织 腹部成形术中控制血清肿块的粘合剂。该方案的科学前提是：1)BP胶 是第一种达到同等剪切强度的水性超强弹性组织粘合剂(80kpa) 通过物理粘合的方式连接到Dermabond®(氰基丙烯酸酯)和TissGlu®。无有毒化学交联剂 参与BP胶的粘连；2)BP胶有效地防止临床前动物的血清形成 3)BP胶粘附机理模拟了英吉利-常春藤在其下分泌纳米颗粒的机理 由英吉利-常春藤离子交联，形成能够粘结到粗糙表面的互锁，如 建筑物、树木或生物组织与颗粒堆积理论相结合，在此理论下进行复合 具有最佳尺寸差异的颗粒最大限度地提高了所得复合材料的粘结强度。这个 这项提议的预期结果是，我们将开发一种完全合成的、受生物启发的、有弹性的和超级的 强生物降解性水性密封胶，BP胶具有优于 现有的粘合剂，以解决具有挑战性的临床问题，以管理后的浆液瘤预防 腹部成形术。

Project Summary Seroma is the most common adverse effect of many surgical procedures and is estimated to occur in up to half of all abdominoplasties. Because abdominoplasty is one of the most commonly performed aesthetic procedures in the United States (150,000/year) seroma formation is a major concern. Problems related to seroma accumulation include patient discomfort, incisional disruption and surgical site infection. These problems lead to additional undesirable procedures, diminish cosmetic outcomes and significantly escalate healthcare costs. Various strategies have been utilized to mitigate postoperative seroma occurrence including surgical approach, talc instillation, closed suction drains, immobilization, fibrin/thrombin sprays, compression, and sclerosants. All of the approaches seek to obliterate the dead space by facilitating the re-adherence of disrupted tissue planes. Currently available commercial adhesives include fibrin glues and biopolymers, such as BioGlue®/Tisseel® and TissuGlu®, respectively. These products are limited by their poor performance in aqueous environments, weak adhesion on wet tissues, short degradation time, dangerously high swelling ratios, and/or cytotoxicity due to toxic chemical crosslinking for adhesion. Clinical outcomes are often unsatisfactory and post-operative seroma formation is common even when the current adhesives are used as an adjunct to drains. The Objective of this STTR Phase I proposal is to develop Aleo BME’s proprietary super-strong and elastic biphasic glue (BP Glue) for the prevention of post-operative seroma following abdominoplasty. The novelty of BP Glue lies in the adoption of a unique adhesion mechanism that combines a plant-inspired bioadhesion strategy and particle packing theory borrowed from the cement industry for the development of an aqueous biomimetic wet tissue adhesive for seroma control in abdominoplasty. The scientific premise of the proposal is as follows; 1) BP Glue is the first aqueous super-strong elastic tissue adhesive to achieve equivalent shear strengths (80 KPa) to Dermabond® (cyanoacrylate) and TissuGlu® through physical bonding. No toxic chemical crosslinking is involved in BP Glue adhesion; 2) BP Glue is effective to prevent seroma formation in a preclinical animal model, and 3) BP Glue adhesion mechanism simulates that of English-Ivy under which nanoparticles secreted by English-Ivy are ionically crosslinked to form an inter-locking capable of binding to rough surfaces, such as buildings, trees or biological tissues in combination with that of particle packing theory under which compositing particles with optimal size difference maximizes the cohesive strength of the resultant composite materials. The expected outcome of this proposal is that we will develop a new fully synthetic, bioinspired, elastic, and super- strong biodegradable aqueous adhesive sealant, BP Glue with superior physiochemical properties over the existing adhesives to address the challenging clinical problems in the management of seroma prevention post- abdominoplasty.