New strategies to target multiple drug resistance in clinically relevant fungal infections.

社区和医院中出现的多重耐药（MDR）被认为是对公共卫生的主要威胁。机会性念珠菌的真菌血流感染尤其值得关注。唑类药物是临床应用最广泛的一类抗真菌药物，但其疗效受到MDR的严重限制。该项目将采用全面的跨学科方法开发用于对抗真菌MDR的新型小分子疗法。

The emergence of multiple drug resistance (MDR) in the community and hospitals is considered a major threat to public health. Fungal bloodstream infections with opportunistic Candida species are of particular concern. Azoles are the most widely used class of antifungals in clinical use, but their efficacy is severely limited by the development of MDR. This project will employ a comprehensive, cross-disciplinary approach to develop novel small-molecule therapeutics for combatting fungal MDR.