Motion-robust brain MRI for infants

项目摘要/摘要 此SBIR/STTR快速通道提交的目标是提供一个软件解决方案，以减少影响 婴儿脑部核磁共振检查中的头部运动。因为结构性核磁共振扫描产生高分辨率图像 而且不会使患者暴露在辐射中，它已经成为一种非常有价值的诊断工具，特别是对 在婴儿样本中对大脑进行成像。每年在中国进行价值约200亿美元的脑部核磁共振检查 美国，包括500,000个婴儿扫描。对于MRI来说，最大的问题是它对患者运动的敏感性。 大约20%的临床大脑核磁共振成像因运动浪费而失真，每年约40亿美元。目前，核磁共振运动是 通过重复扫描或麻醉来处理。这两种方法都会降低吞吐量，同时增加成本， 患者负担和健康风险。在婴儿中，麻醉会导致脑损伤，导致FDA的黑匣子 对3岁以下儿童的警告。因此，婴儿的脑部核磁共振检查的标准是 并抱着最好的希望。 尽管需求很大，但目前还没有与婴儿兼容的核磁共振运动监测系统。基于摄像头的 系统在与婴儿一起使用时遇到严重限制-只有FIRMM的纯软件方法才能工作 轻松、可靠。在SBIR/STTR奖的支持下，必须克服两个障碍才能发展 FIRMM-研究和临床使用的婴儿。1)适合婴儿使用的运动感知/矫正版本 必须生成序列(T1w、T2w)。2)FIRMM-婴儿可用性及其提高MRI质量的能力 必须得到证明。 拟议的研究重点是为FIRMM-婴儿(第一阶段)和建筑提供概念验证 跨供应商验证FIRMM-Baby的临床就绪版本(第二阶段)。FIRMM-婴儿设备 为扫描操作员和医生提供实时运动信息，并与vNav Ready相结合 运动感应序列将使磁共振扫描更安全、更快、更便宜，适合婴儿成像。

Project Abstract/Summary The objective of this SBIR/STTR Fast Track submission is to provide a software solution to reduce the effects of head motion during brain MRIs of infants. Because structural MRI scanning produces high-resolution images and does not expose patients to radiation, it has become an immensely valuable diagnostic tool, particularly for imaging the brain in infant samples. Approximately $20 billion worth of brain MRIs are performed each year in the US, including 500,000 infant scans. The greatest problem for MRI is its susceptibility to patient motion. About 20% of clinical brain MRIs are distorted by motion – wasting ~$4 billion/year. Currently, MRI motion is dealt with by repeating scans or anesthesia. Both approaches diminish throughput, while increasing costs, patient burden, and health risks. In infants, anesthesia causes brain injury, leading to an FDA blackbox warning against it for children under 3 years old. Thus, the standard of brain MRI care in infants is swaddling them and hoping for the best. There are no infant-compatible MRI motion monitoring systems, despite the great need. Camera-based systems encounter critical limitations when used with infants – only FIRMM's software-only approach can work easily and reliably. Two obstacles must be overcome with support from this SBIR/STTR award to develop FIRMM-infant for research and clinical use. 1) Infant-compatible versions of motion-sensing/correcting sequences must be generated (T1w, T2w). 2) FIRMM-infant usability and its ability to improve MRI quality must be demonstrated. The proposed research focuses on delivering proof-of-concept for FIRMM-infant (Phase I) and building and validating a clinical-ready version of FIRMM-infant across vendors (Phase II). The FIRMM-infant device provides scan operators and physicians with real time motion information, and in combination with vNav ready motion sensing sequences will MR scans safer, faster, and less expensive for infant imaging.