Shared Resource for Disease Model Surgical Critical Care and Data Mangement

描述(由申请人提供)：宾夕法尼亚大学学术外科、介入放射学和心脏病学社区的几名成员正在解决基础和翻译研究中的关键问题，这些研究需要使用大型动物模型。尽管干预措施复杂且与相关临床领域中使用的一些最复杂的技术平行，但这项研究中新兴的限速过程是需要一个同样复杂的麻醉工作流程环境。我们特别申请这笔资金，以购买一对具有内置重症监护监测和数据存储/检索/分析功能的辅助麻醉机，用于一种设置的体外循环和另一种设置的MRI。这两种仪器都通过一个通用的集成数据管理系统传递详细的、时间同步的生理信息。拟议的共享设备采购将极大地加快许多NIH、行业和基金会支持的研究人员的研究计划，并得到外科部门和大学实验室动物资源的支持。获得拟议的共享资源还将有助于巩固宾夕法尼亚大学医学院和兽医学院的麻醉和外科危重护理学术社区。这将直接有利于以大学为基础的研究项目，这些项目旨在改善心脏病、癌症、遗传病和先天性疾病患者的医疗保健。 公共卫生相关性：这项拨款提案寻求在我们共享的大型动物中发展一个麻醉/重症护理环境，以匹配我们现有的癌症、心血管和遗传疾病外科干预方面的翻译研究计划的复杂性。

DESCRIPTION (provided by applicant): Several members of the University of Pennsylvania Academic Surgery, Interventional Radiology, and Cardiology communities are addressing critical issues in basic and translational research that necessitate the use of large animal models. Although the interventions are complex and parallel some of the most sophisticated techniques used in the related clinical fields, the emerging, rate-limiting process in this research is the need for an equally sophisticated anesthesia workflow environment. We are specifically requesting the funds to purchase a pair of complementary anesthesia machines with built-in critical care monitoring and data storage/retrieval/analysis function for use with cardiopulmonary bypass in one setting and MRI in the other setting. Both instruments communicate detailed, time-synchronized physiological information with a common integrated data management system. The proposed shared equipment purchase will dramatically accelerate the research programs of numerous NIH, industry, and foundation supported investigators, and has the backing of the Departments of Surgery and the University Lab Animal Resources. Access to the proposed shared resource will also serve to nucleate the academic anesthesia and surgical critical care communities of both the University of Pennsylvania Schools of Medicine and Veterinary Medicine. This will have direct benefit to the University based research programs that seek to improve healthcare for patients with heart disease, cancer, genetic and congenital disorders. PUBLIC HEALTH RELEVANCE: This grant proposal seeks to develop an anesthesia/critical care environment in our shared large animal vivarium, to match the sophistication of our existing translational research program in surgical interventions for cancer, cardiovascular and genetic diseases.