The UTSW Small Animal SPECT-CT for Molecular Imaging Research and Education

描述（由申请人提供）：本申请的目的是购买用于体内小动物扫描的BioScan纳米spect - ct扫描仪。请求的购买价格是$1,063,916。获得该扫描仪将满足未满足的校园范围内的需求：注射单光子发射放射性示踪剂的小鼠和大鼠的高分辨率小动物成像。该扫描仪将允许由13名NIH资助的科学家组成的杰出小组更优化地使用多年来创建的动物模型。在神经生物学和神经肿瘤学、心血管生物学和疾病、关节炎、自身免疫（狼疮）、肿瘤学和放射化学等领域，共有21项NIH拨款得到支持。此外，我们设想了一个程序，其中扫描仪将部分满足下一代分子成像仪和放射科医生的教育成像需求。在收到制造商的报价后选择了扫描仪。一个由PI（放射学家-科学家）、物理学家和放射化学家组成的3名科学家组成的小组主要评估可用的商用扫描仪。对每个主要供应商进行了对安装地点、制造商工厂或虚拟演示的现场访问。在考虑了主要用户的需求后，扫描仪的分辨率、灵敏度、安装基础和易用性是主要因素。BioScan NanoSPECT-CT被认为是我们用户的最佳选择。购买扫描仪将立即为德州大学西南分校创造2个新的工作岗位。一旦调查人员成功使用扫描仪，可能会产生新的资金，可能会导致其他工作。对人类疾病模型的SPECT/CT成像应用所产生的理解，可能会带来新的治疗方法，并改善美国人民的医疗保健。

DESCRIPTION (provided by applicant):: The objective of this application is the purchase of a BioScan NanoSPECT-CT scanner for in vivo small animal scanning. The requested purchase price is $1,063,916. Acquisition of the scanner will fulfill an unmet campus- wide need: high resolution small animal imaging in mice and rats injected with single photon emitting radiotracers. The scanner will permit a distinguished group of 13 NIH funded scientists to more optimally use animal models that have been created over years. A total of 21 NIH grants are supported in areas of neurobiology and neuro-oncology, cardiovascular biology and disease, arthritis, autoimmunity (lupus), oncology, and radiochemistry. Furthermore, we envisage a program in which the scanner will partially fulfill the educational imaging needs of the next generation molecular imagers and radiologists. The scanner was chosen after receiving quotes from the manufacturers. A team of 3 scientists, comprised of the PI (Radiologist- scientist), physicist, and a radiochemist, was formed to primarily evaluate the available commercial scanners. Site visits to installation sites, manufacturer's plants, or virtual demos were conducted for each of the major vendors. Scanner resolution, sensitivity, installed base, and ease of use were the dominant factors after considering the needs of the major users. The BioScan NanoSPECT-CT was considered the best choice for our users. Purchase of the scanner will lead to an immediate creation of 2 new jobs at UT Southwestern. Once investigators successfully use the scanner it is likely new funding will result that might lead to other jobs. The understanding that will result from application of SPECT/CT imaging of models of human disease may potentially lead to new therapies and improved healthcare for the American people. PUBLIC HEALTH RELEVANCE: Small animal models of human diseases are important for advancing understanding of disease pathogenesis and disease treatment. Imaging studies in these animal models are critical for model validation, to follow disease progression, to monitor therapy efficacy, and minimize animal use. Purchasing the scanner will enhance research in these areas, potentially improve healthcare, and lead to creation of two jobs.