GE Healthcare Discovery MR750 3T MRI System

描述（申请人提供）：本提案的具体目的是获得资金以购买GE Healthcare Discovery MR 750 3 T人体全身磁共振成像（MRI）系统，该系统将安装在新建的，位于威斯康星大学麦迪逊分校校园内的最先进的医学研究机构，名为威斯康星州医学研究所（WIMR）（UW-Madison）。目前，MRI是70多名UW研究人员的主要研究重点。这些研究人员组成了一个多学科小组，包括来自医学物理学，放射学，生物医学工程，物理学，工程学，数学，计算机科学等部门的教职员工和学生。该研究的主要重点是开发新的采集和重建方法，以提高临床医学MR成像的诊断能力，从而改善全球医疗保健。目前的项目集中在快速成像、非笛卡尔采集轨迹、解剖血管成像、血液和脑脊液（CSF）的流动成像、压力标测、造影剂动力学的高时间分辨率成像、功能性脑标测、原发性和继发性肝癌成像、肝脏储存成像、超极化气体成像、高空间分辨率乳腺成像、高空间分辨率软骨降解生物标志物成像、MRI引导治疗、射频（RF）发射/接收线圈开发、非笛卡尔采集轨迹的并行成像、解剖和功能肾成像、脂肪和水分离以及许多其他主题。除了从事磁共振成像研究的研究者外，还有超过25名研究者的研究项目部分依赖于磁共振成像。这些研究人员研究的主题包括癌症的治疗计划、癌症的治疗反应、心血管介入应用的多模态图像融合、阿尔茨海默病的进展及其对治疗的反应、成人和儿童癫痫的进展及其对治疗的反应、中风对吞咽的影响和对舌头练习的反应、损伤对肌肉形态和功能的影响、还有很多其他的医学问题。在威斯康星大学麦迪逊分校，有一个跨部门和跨学科的合作是必要的推进临床和基础科学的悠久传统。GE Healthcare Discovery MR 750 3 T MRI系统位于研究机构内，与医院相连，并严格致力于研究活动，该系统的可用性将为MRI研究项目的快速发展提供宝贵和必要的资源，从而增强对人类疾病的理解，并促进MR成像方法和技术的进步，从而提供更强的诊断能力。将在该系统上进行的MRI研究活动的目标是改善全人类的医疗保健。 公共卫生相关性：威斯康星大学麦迪逊分校的研究人员有开发新型磁共振成像（MRI）方法的历史，这些方法导致了现代医学成像的进步和人类疾病诊断的改进。专门用于医学成像研究的3 T MRI扫描仪的可用性将：i）加速这些方法从实验室到诊所的翻译，ii）允许完成和继续现有项目，允许保留UW教职员工和学生，iii）促进未来资金的获得，使当前的保留成为可能，并招募未来的研究人员，以及iv）导致医学成像的新特征的开发，这将在商业部门中提供更多的就业机会，并且甚至可能导致医疗保健成本的降低。购买MR 750对环境有积极的影响，因为GE有几个“绿色”解决方案，例如翻新和回收计划，其中94%的材料被重复使用，重新部署或回收，并且在运行过程中，MR 750具有低能耗要求，消耗品很少。

DESCRIPTION (provided by applicant): The specific aim of this proposal is to obtain funding to purchase a GE Healthcare Discovery MR750 3T Human Whole-Body Magnetic Resonance Imaging (MRI) system to be installed in the Imaging Sciences Center of a newly-constructed, state-of-the-art medical research facility named the Wisconsin Institutes for Medical Research (WIMR) located on the campus of the University of Wisconsin-Madison (UW-Madison). Currently, MRI is the main research focus of more than 70 UW investigators. These investigators comprise a multi-disciplinary group, including faculty, staff, and students from the departments of Medical Physics, Radiology, Biomedical Engineering, Physics, Engineering, Mathematics, Computer Science, and others. The main emphasis of the research is developing new acquisition and reconstruction methods for enhancing the diagnostic capabilities of clinical medical MR imaging in order to improve healthcare worldwide. Current projects focus on rapid imaging, non-Cartesian acquisition trajectories, anatomic vascular imaging, flow imaging of blood and cerebrospinal fluid (CSF), pressure mapping, high temporal resolution imaging of contrast material kinetics, functional brain mapping, primary and secondary liver cancer imaging, hepatic storage imaging, hyperpolarized gas imaging, high spatial resolution breast imaging, high spatial resolution cartilage degradation biomarker imaging, MRI-guided therapy, radiofrequency (RF) transmit/receive coil development, parallel imaging for non-Cartesian acquisition trajectories, anatomic and functional renal imaging, fat and water separation, as well as a host of other topics. In addition to the investigators who perform MR imaging research, there are more than 25 investigators whose research projects rely partially on MRI. These investigators study topics such as treatment planning for cancer, treatment response of cancer, multi-modality image fusion for cardiovascular interventional applications, progression of Alzheimer's disease and its response to therapy, progression of epilepsy in adults and children and its response to therapy, the impact of stroke on swallowing and response to tongue exercises, the effects of injury on muscle morphology and function, and many other medical issues. At UW-Madison, there is a long-standing tradition of inter-departmental and inter-disciplinary collaborations that are necessary for advancing clinical and basic science. The availability of the GE Healthcare Discovery MR750 3T MRI system, conveniently located in a research facility, connected to the hospital, and devoted strictly to research activities, will provide a valuable and necessary resource for the rapid advancement of MRI research projects that will lead to enhanced understanding of human diseases and advances in MR imaging methods and technologies that will provide greater diagnostic capabilities. The goal of the MRI research activities that will be performed on this system is to improve healthcare for all humankind. PUBLIC HEALTH RELEVANCE: Researchers at the University of Wisconsin-Madison have a history of developing novel magnetic resonance imaging (MRI) methods that have led to advances in modern medical imaging and improvements in diagnosing human diseases. Availability of a 3T MRI scanner that is dedicated solely to medical imaging research will: i) accelerate the translation of these methods from the lab to the clinic, ii) permit completion and continuation of existing projects permitting retention of UW faculty, staff, and students, iii) facilitate the acquisition of future funding, making possible retention of current, and recruitment of future, researchers, and iv) lead to the development of new features for medical imaging that will provide increased jobs in the commercial sector and may even lead to reductions in healthcare costs. Acquisition of the MR750 has positive impact on the environment, since GE has several "green" solutions such as a refurbishment and recycling program where 94% of materials are reused, redeployed, or recycled, and during operation, the MR750 has low energy requirements and requires very few consumables.