A High-End 3 Tesla Human MRI Scanner Dedicated to Research

描述(由申请人提供)：伊利诺伊大学芝加哥分校(UIC)请求拨款支持购买最先进的3特斯拉(3T)全身磁共振成像(MRI)扫描仪，以执行先进的解剖、功能、光谱和生理成像，用于生物医学研究。迫切需要所要求的3T磁共振扫描仪，以(A)适应迅速增加的NIH资助项目，(B)用尖端的3T技术取代早期一代、过时、无法升级的3T扫描仪，以及(C)建立首个专门在UIC进行研究的3T成像设施。拟议的3T扫描仪对于UIC保持和加强其在成像技术前沿的地位，以及确保成功完成15个NIH资助的在建项目(11个R01‘S、1个P50、1个R21、1个K24和1个R03)至关重要，总金额为3260万美元。最先进的核磁共振扫描仪还将在我们未来在广泛的基础、翻译和临床研究领域从脑成像扩展到身体成像方面发挥关键作用。总体而言，UIC迫切需要一台专门用于研究的高端3T扫描仪。所要求的仪器是一台3T通用电气发现MR750扫描仪，具有先进的神经和身体成像能力，由尖端技术实现。3T扫描仪将被用作位于医学院的大学范围的资源。该大学分配了至少2500平方英尺的空间来容纳新的3T核磁共振设施。安装、操作和维护3T扫描仪的大量基础设施和技术专长已经到位。更重要的是，UIC及其医学院已承诺为拟议中的新3T设施提供117万美元，用于支付空间翻新、场地准备、扫描仪安装和运营成本。为了确保在获奖后期间继续成功运作，将成立一个项目审查委员会，根据国家卫生研究院的指导方针分配3T资源，并在确保科学价值和生产率的同时促进设备使用。此外，还将设立一个咨询委员会，以监督这笔赠款的管理，并作出政策和战略决定。这一行政结构伴随着一项财务计划，以确保在授标后期间实现自给自足。我们3T成像设施的使命是促进磁共振成像技术在广泛的生物医学学科中的开发和协同应用。购买新的3T扫描仪是完成这一使命的关键和重要的一步。

DESCRIPTION (provided by applicant): The University of Illinois at Chicago (UIC) requests grant support to purchase a state-of-the- art whole-body 3 Tesla (3T) magnetic resonance imaging (MRI) scanner to perform advanced anatomic, functional, spectroscopic and physiologic imaging for biomedical research. The requested 3T MRI scanner is urgently needed to (a) accommodate a rapidly increasing number of NIH-funded projects, (b) replace an early generation, out-dated, un-upgradable 3T scanner with cutting-edge 3T technologies, and (c) establish the first-ever 3T imaging facility dedicated to research at UIC. The proposed 3T scanner is of paramount importance for UIC to sustain and strengthen its position at the forefront of imaging technology and to ensure successful completion of fifteen active NIH-funded projects (eleven R01's, one P50, one R21, one K24, and one R03) with a total award of $32.6M. The state-of-the-art MRI scanner will also play a pivotal role in our future expansion from brain to body imaging over a broad range of basic, translational, and clinical research areas. Overall, there is a compelling need for a high-end 3T scanner dedicated to research at UIC. The instrumentation requested is a 3T General Electric Discovery MR750 scanner with advanced neuro- and body-imaging capabilities enabled by cutting-edge technologies. The 3T scanner will be utilized as a University-wide resource located in the College of Medicine. At least 2,500 square feet of space is allocated by the University to house the new 3T MRI facility. Substantial infrastructure and technical expertise are already in place for installing, operating and maintaining the 3T scanner. More importantly, UIC and its College of Medicine have committed $1.17M to the proposed new 3T facility to cover space renovation, site preparation, scanner installation, and operation costs. To ensure continued successful operation in the post-award period, a Project Review Committee will be created to allocate the 3T resource according to the NIH guidelines and promote equipment usage while ensuring scientific merit and productivity. In addition, an Advisory Committee will be created to oversee the management of this grant and make policy and strategic decisions. This administrative structure is accompanied by a financial plan that ensures self-supporting in the post-award period. The mission of our 3T imaging facility is to promote the development and synergistic application of MRI techniques to a broad range of biomedical disciplines. The purchase of the new 3T scanner is a critical and significant step to accomplish this mission.