SMOKING AS A NOVEL RISK FACTOR IN THE PROGRESSION OF RENAL DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 吸烟与肾脏疾病的发展有很强的相关性，表现为肾脏疾病的加速发展，蛋白尿，甚至终末期肾脏疾病。我们的中心假设是，吸烟通过诱导内皮功能障碍、炎症和氧化应激导致血压升高和肾脏血流量相对减少而加速肾脏进展。我们将研究50名吸烟者和50名不吸烟者的不同程度的肾功能障碍，以及25名吸烟者和25名肾功能正常的非吸烟者。该项目将量化吸烟者和非吸烟者肾脏疾病的进展，并确定全身和/或肾脏血流动力学变化是否会导致肾功能丧失。该项目将调查吸烟导致的内皮功能障碍在肾脏进展中的作用。该项目将确定吸烟引起的全身和/或肾脏炎症是否与肾脏疾病进展更快有关。期末项目将研究吸烟引起的氧化变化在肾脏进展中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is a strong association of smoking tobacco with the development of renal disease manifested by enhanced progression of renal disease, proteinuria, and even end-stage renal disease. Our central hypothesis is that smoking accelerates renal progression by inducing endothelial dysfunction, inflammation, and oxidative stress leading to an increase in blood pressure and a relative decrease in renal blood flow predisposing to renal progression. We will study 50 smokers and 50 nonsmokers with varying levels of renal dysfunction serum creatinine 2.0-5.0 secondary to hypertension-associated renal disease along with 25 smokers and 25 nonsmokers with normal renal function. Project will quantify the progression of renal disease in smokers and nonsmokers and determine whether systemic and/or renal hemodynamic changes lead to loss of renal function. Project will investigate the role of smoking-induced endothelial dysfunction in renal progression. Project will determine whether systemic and/or renal inflammation induced by smoking is associated with more rapid progression in renal disease. The final Project will study the role of smoking induced oxidative changes in renal progression.