CLINICAL TRIAL: FOLLOW-UP STUDY: NERUAL TISSUE TRANSPLANTATION IN SYRINGOMYELIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 PTS是一种进行性疾病，其中脊髓内的含有液体的空腔或囊肿随着时间的推移而膨胀和伸长。 囊肿的上行扩张导致疼痛，在原始损伤部位以上的水平失去感觉和运动功能。 为了尽量减少进一步的神经恶化，脊髓分流术用于引流扩张的空洞，但这些并不能永久阻止PTS的进展。 全世界的动物研究表明，将胎儿神经组织移植到临床相关的脊髓损伤中，可以生长并完全填充人类脊髓损伤中出现的囊性空洞。 因此，初步研究测试了一种假设，即将胎儿组织置于人体的空洞中会起到栓塞的作用，从而防止进一步扩张。 实验还测试了胎儿神经移植物是否对受体的神经功能或日常生活活动产生不利影响。 运动和感觉功能，残疾和疼痛进行了定量评估术前和术后使用既定的方法。 通过一系列磁共振成像MRI检查确定移植物存活和生长。 记录体感诱发电位，以评估胎儿组织是否对长的上行白色物质束中的神经冲动传导有任何影响。 这项随访研究的目的是审查移植后6至9年入组研究受试者的结局，并测试目前的疼痛水平、感觉和运动障碍、临床评分和脊髓空洞的状态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PTS is a progressive disorder in which a fluid-containing cavity or cyst within the spinal cord expands and elongates over time. Ascending expansion of the cyst causes pain, loss of sensory and motor function at levels above the original site of injury. To minimize further neurological deterioration, spinal shunts are used to drain the expanding syrinx, but these do not permanently halt the progression of PTS. In animal studies worldwide, it had been shown that fetal neural tissue transplants into clinically relevant spinal injuries grew and completely filled areas of cystic cavitations seen in human spinal cord injury. Therefore, the pilot study tested the hypothesis that fetal tissue placed into a syrinx in humans would act as a plug, and thereby prevent further expansion. The experiment also tested whether fetal neural grafts adversely impacted the recipients neurological functions or activities of daily living. Motor and sensory function, disability, and pain were quantitatively evaluated both pre- and post-operatively using established methods. Determination of transplant survival and growth were made from serial magnetic resonance imaging MRI exams. Somatosensory evoked potentials were recorded to assess whether the fetal tissue had any impact upon the conduction of nerve impulses in the long ascending white matter tracts. The purpose of this follow-up study is to review the outcomes of the enrolled research subjects at six to nine years post-transplant and to test current levels of pain, sensory and motor impairment, clinical scoring, and status of the syringomyelia cavity.