EMOTIONS AND HEART FAILURE OUTCOMES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是探讨两种潜在的机制，已知抑郁症和HF发病率和死亡率增加之间的联系。 具体的目的是确定SNS唤醒，促炎细胞因子水平的改变和不依从性是否有助于抑郁症和较差的HF结果之间的关联。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to explore two potential mechanisms for the known association between depression and increased morbidity and mortality in HF. The specific aim is to determine whether SNS arousal, alterations in proinflammatory cytokine levels and nonadherence contribute to the association between depression and poorer HF outcomes.