Pre-clinical Assessment Core

摘要 翻译研究的目的是促进和促进基础科学的技术进步 到临床活体领域，以促进患者护理。临床前评估核心(PAC)将 作为一个平台，通过提供设施，促进体外研究进展转化为临床实践 以及将潜在技术转化为临床前建模的专业知识。政治行动委员会成立于克莱姆森 大学使用动物模型和最近建立的肌肉骨骼创新研究的悠久历史 克莱姆森大学生物医学工程创新园区(CUBEInC)。政府账目委员会将会综合这些现有的 克莱姆森大学和格林维尔健康中心创新转化的研究资源和专业知识 将联合国系统整合为一个全面的专家和服务网络，并将其组织成两个相辅相成的支柱： 动物建模与死后评估(AM-PMA)和人体身体建模(HCM)。AM- PMA推进器建立在克莱姆森大学主校区已建立的AAALAC认证的研究设施基础上 为动物采购、管理和实验提供最先进支持的园区 学习。其中包括戈德利-斯内尔研究中心和克莱姆森大学农场。另外， 它包括克莱姆森大学的组织技术设施，包括最先进的加工 常规组织学和硬组织/金属处理设备，包括免疫组织化学和 成像。HCM的推进建立在已建立的Bioskills外科培训和创新中心基础上，并 CUBEInC上的其他资源。帐委会领导班子将由两位著名的联合董事组成。 临床医生和科学家，以及由技术专家和科学家组成的支持小组。的总体使命 PAC将为所有SC-TRIMH调查人员提供使用活动物的指导和战略规划 在他们的研究计划中加入模型和/或人体身体模型，以加强他们的研究、创新 以及在肌肉骨骼健康领域的竞争力。通过PAC，SC-TRIMH调查人员将了解 如何开发和实施与肌肉骨骼应用相关的临床前研究，并评估 他们的研究成果。此外，政府账目委员会将为高级公务员提供翻译专业知识、支援和培训。 TRIMH调查人员，以及南卡罗来纳州克莱姆森大学的其他PI，以及IDEA网络。 临床前评估核心是肌肉骨骼研究人员的关键资源，其具体目标是 1)通过“交钥匙”方法为临床前建模提供专业知识和支持，2)支持初级 研究人员开发新的临床前评估模式和3)增强体内和外部 培养体内临床前研究能力，提高对该设施的认识，增加对用户的关注 对肌肉骨骼和支持SC-TRIMH中心的结合。科布雷基金将支持训练有素的 技术人员和资源导师，以确保核心设施的运行和维护 以及对SC-TRIMH研究人员的创新及其翻译的培训和指导。

SUMMARY The purpose of translational research is to foster and facilitate technology advancements from the basic sciences to the clinical in vivo realm for the advancement of patient care. The Pre-Clinical Assessment Core (PAC) will serve as a platform to facilitate the transfer of in vitro advances into clinical practice by providing the facilities and expertise to actuate potential technologies into pre-clinical modeling. PAC is founded on Clemson University's long history of musculoskeletal innovation research using animal models and the recently built Clemson University Biomedical Engineering Innovation Campus (CUBEInC). PAC will consolidate these existing research resources and expertise for the translation of innovations at Clemson University and Greenville Health System into a comprehensive network of experts and services to be organized into two complementary thrusts: Animal Modeling and Post-Mortem Assessment (AM-PMA) and Human Cadaveric Modeling (HCM). The AM- PMA thrust builds on established, AAALAC-accredited, research facilities on the Clemson University main campus that provide state-of-the-art support for animal procurement, management and experimental studies. These include the Godley-Snell Research Center and the Clemson University Farms. Additionally, it includes the Clemson University histotechnological facilities including state-of-the-art processing equipment for both routine histology and hard tissue/metal processing including immunohistochemistry and imaging. The HCM thrust builds on the established Bioskills Surgical Training and Innovation Center and other resources at CUBEInC. The PAC leadership team will consist of the thrusts co-directors, both renowned clinicians and scientists, as well as a support group of technical experts and scientists. The overall mission of PAC is to provide mentoring and strategic planning to all SC-TRIMH investigators for the use of live animal models and/or human cadaver models in their research programs to enhance their research, innovation and competitiveness in the field of musculoskeletal health. Through PAC, SC-TRIMH investigators will learn how to develop and implement pre-clinical studies pertinent to musculoskeletal applications and assess the outcomes of their studies. Additionally, PAC will provide translational expertise, support and training for SC- TRIMH investigators, as well as other PIs at Clemson University, in South Carolina, and the IDeA network. The specific aims of the Pre-Clinical Assessment Core, a critical resource for musculoskeletal researchers, are to 1) provide expertise and support for pre-clinical modeling with a “turnkey” approach, 2) support junior investigator for the development of new models of pre-clinical assessment and 3) enhance the in vivo and ex vivo pre-clinical research capability to foster an increase in awareness of the facilities, increase users focused on musculoskeletal and support the coalescing of SC-TRIMH center. COBRE funds will support highly trained technical personnel and resource mentors to assure the operation and maintenance of core facilities as well as the training and mentoring of SC-TRIMH researchers for innovation and its translation.