Core 5 - Virology, Cell, Molecular & Chemical Biology Core

核心5：病毒学，细胞，分子和化学生物学核心 总结 CRNA研究人员拥有广泛的病毒学、细胞和分子生物学专业知识， 化学结构生物学每一个以生物学为重点的项目都需要应用 这些领域的技术和专业知识。为便于确定结构化的新目标， 和生物物理分析，并促进结构和 生物物理数据，病毒学，细胞，分子和化学生物学核心将承担一些 活动包括：（1）使用CLIP发现结构功能研究的新RNA靶点（2） 使用DMS-MaPseq（3）siRNA测定细胞中的RNA二级结构， sCAS 9/SAM筛选以鉴定和验证用于结构功能研究的新蛋白质靶标（4） 提供病毒学和一般分子生物学支持， 项目和目标（5）虚拟筛选和化学合成，使RNA的发现- CRNA中研究的生物过程的靶向抑制剂。

Core 5: Virology, Cell, Molecular and Chemical Biology Core Summary CRNA investigators have a wide range of expertise virology, cell and molecular biology, as well as chemical structural biology. Each of the biologically focused projects requires the application of techniques and expertise in these areas. To facilitate the identification of new targets for structural and biophysical analysis, and to facilitate the validation and biological interpretation of structural and biophysical data, the Virology, Cell, Molecular and Chemical Biology Core will undertake a number of activities including: (1) the discovery of new RNA targets for structure function studies using CLIP (2) the determination of RNA secondary structures in cells using DMS-MaPseq (3) siRNA and sCAS9/SAM screening to identify and validate new protein targets for structure function studies (4) the provision of virology and general molecular biology support to biologically and structurally focused projects and aims (5) virtual screening and chemical synthesis to enable the discovery of RNA- targeted inhibitors of the biological processes studied in the CRNA.