Tailored Influenza Vaccination Screening and Communication for Hospitalized Children and Families

项目摘要/摘要 这份提案描述了一项为期五年的研究和职业发展计划，该计划将允许霍夫施泰特博士 实现她的目标，成为一名独立的临床研究员，进行以患者为中心的比较 与儿科疫苗接种相关的有效性研究。她提出的项目旨在增加流感 确定和满足流感疫苗决策需求对住院儿童疫苗接种率的影响 和父母的偏好，并通过使用健康减少流感疫苗的交付障碍 信息技术。这项建议建立在她在儿科医学、流行病学和基础知识方面的培训基础上。 研究和生物统计学方法，以及她以前审查及时接种疫苗覆盖率的经验， 疫苗有效性和安全性，以及疫苗提醒/召回制度的影响。这项建议提供了一种 霍夫施泰特博士将如何通过高级课程和 在定性和参与性设计方法、相对有效性方面的其他学习机会 研究、卫生信息学、传播和实施学。霍夫施泰特博士将主持 在一个独特的丰富和支持性的环境中拟议的研究和职业发展活动。她会的 从在呼吸道病毒感染和免疫方面拥有专业知识的教职员工那里获得卓越的指导， 定性、参与性设计和比较有效性研究，以及基于技术的干预措施。 在这项提案的第一个目标中，霍夫施泰特博士将对父母进行调查，并对父母进行深入访谈， 护士和医生识别和了解与流感疫苗接种有关的因素 住院的儿童。她将专注于父母疫苗决策，疫苗提供者沟通，以及 流感疫苗投放的障碍。在第二个目标中，她将举办快速流程设计研讨会， 利用收集的信息并积极与主要利益攸关方接触以开发定制的流感 疫苗接种筛查和沟通工具。然后，她将与一个专家小组和Beta测试者合作，以 在医院的电子健康档案中进一步提炼和整合这一工具。在第三个目标中，她将进行一次 随机整群交叉试验，以评估该工具与标准流感的效果 流感疫苗接种筛选工具在符合疫苗条件的住院儿童中的应用 在接种疫苗方面的家长探视经验。这些研究将提供有关父母的关键信息 疫苗决策阶段和影响因素，有效的提供者疫苗沟通做法， 以及使用定制的基于技术的工具来改善与疫苗相关的结果。 最终，这项提案将允许霍夫施泰特博士开发一项独立的、高质量的研究计划 致力于提高推荐疫苗在不同人群和环境中的及时性 新的以病人和家庭为中心的方法。

PROJECT SUMMARY/ABSTRACT This proposal describes a five-year research and career development plan that will allow Dr. Hofstetter to achieve her goal of becoming an independent clinical investigator conducting patient-centered comparative effectiveness research relevant to pediatric vaccination. Her proposed project aims to increase influenza vaccine uptake in hospitalized children by identifying and meeting the influenza vaccine decision-making needs and preferences of parents and reducing influenza vaccine delivery barriers through the use of health information technology. The proposal builds upon her training in pediatric medicine, epidemiology, and basic research and biostatistical methods as well as her prior experience examining timely vaccination coverage, vaccine effectiveness and safety, and the impact of vaccine reminder/recall systems. This proposal provides a detailed plan of how Dr. Hofstetter will enhance her knowledge and skillset through advanced coursework and other learning opportunities in qualitative and participatory design methodology, comparative effectiveness research, health informatics, and dissemination and implementation science. Dr. Hofstetter will conduct the proposed research and career development activities in a uniquely rich and supportive environment. She will receive exceptional mentorship from faculty with expertise in respiratory viral infections and immunizations, qualitative, participatory design, and comparative effectiveness research, and technology-based interventions. In the first aim of this proposal, Dr. Hofstetter will survey parents and conduct in-depth interviews of parents, nurses, and physicians to identify and understand the factors associated with influenza vaccination of hospitalized children. She will focus on parent vaccine decision-making, provider vaccine communication, and barriers to influenza vaccine delivery. In the second aim, she will conduct rapid process design workshops that utilize the information gathered and actively engage key stakeholders to develop a tailored influenza vaccination screening and communication tool. She will then work with an expert panel and beta-testers to further refine and integrate this tool in the hospital’s electronic health record. In the third aim, she will conduct a randomized cluster-crossover trial to assess the effect of this tool compared to the standard influenza vaccination screening tool on influenza vaccine uptake among vaccine-eligible hospitalized children and on parent visit experience in the vaccination context. These studies will provide critical information about parent vaccine decision-making stages and influencing factors, effective provider vaccine communication practices, and the use of a tailored technology-based tool to improve vaccine-related outcomes. Ultimately, this proposal will allow Dr. Hofstetter to develop an independent, high-quality research program dedicated to improving timely uptake of recommended vaccines in diverse populations and settings using novel patient- and family-centered approaches.