Shared Resources Core: Puerto Rico Biobank

项目摘要/摘要 为了更接近实现精准医疗和个性化癌症护理的目标， 代表所有族裔的大量个人参与生物库是至关重要的。这个 现有生物库中来自种族和少数族裔的组织稀缺，这是一个很大的限制 开展必要的研究，以了解健康差距的生物学基础。因为癌症- 导致不同个体和种族的基因改变，精准医学的实践需要 通过对肿瘤组织的研究获得的知识，这些组织来自代表不同 人口。重要的是要认识到，西班牙裔/拉丁裔(H/L)种族是欧洲人、 非洲人和美洲印第安人的祖先基因组，其比例在不同的个体之间差异很大 不同的地理区域。此外，与癌症生物学和癌症生物学相关的癌症趋势也存在差异 H/L不同亚群间的混合遗传。尽管是一个很大比例的种族 生活在美国的少数族裔，到目前为止，还没有从H/L那里获得全面的肿瘤组织 国家生物库中的癌症患者。为了解决这一差距，我们建议继续发展现有的 波多黎各生物库(PRBB)的研究基础设施，以支持旨在 了解癌症健康差异的生物学基础。PRBB的目的是促进最优的 收集、加工、储存和分发来自 岛上的H/L人群，用于研究人员发起的转化型癌症研究。在过去的10年里 多年来，波多黎各已经建立了坚实的基础设施，以开发这一独特的生物储存库。穿过 这个资源，新鲜的冰冻组织，石蜡切片，高质量的肿瘤来源的RNA，基因组DNA和临床 风险因素信息可用于支持这两个机构专注于分子方面的研究 与居住在佛罗里达和波多黎各的H/L有关的癌症健康差异的决定因素。 我们建议通过三个具体目标扩大现有伙伴关系的生物库。在目标1中，我们建议 与当地政府合作，继续收集、加工、储存和分发生物检疫制剂 医院和诊所。与伙伴关系的外联核心合作，努力同意健康 在社区外展教育活动中，个人将继续参与。在目标2中，我们建议延长 人口统计、临床、病理和分子数据的记录(‘基因组’、血统、下一代序列 数据)，与量化科学核心合作。在目标3中，我们建议促进新的协作 研究项目的重点是癌症研究。作为翻译研究的促进者，PRBB被放在 精准医学倡议的最前沿方案目标是改进疾病风险预测和 根据基因、生活方式和疾病的个体差异制定诊断和治疗策略 环境，重点关注生物库和研究中代表性不足的人群。

PROJECT SUMMARY/ABSTRACT In order to move closer to achieving the goals of precision medicine and individualized cancer care, participation in biobanking from large numbers of individuals representing all ethnicities is essential. The scarcity of tissues available at existing biobanks from racial and ethnic minorities poses a substantial constraint to conducting research needed to understand the biological basis of health disparities. Because cancer- causing genetic alterations vary across individuals and ethnicities, the practice of precision medicine requires knowledge acquired through the study of tumor tissue derived from individuals representing diverse populations. It is important to recognize that Hispanic/Latino (H/L) ethnicity is an admixture of European, African, and Amerindians ancestral genomes, the proportions of which vary widely across individuals from different geographical regions. Also, there are differences in cancer trends associated to cancer biology and admixture genetics among different H/L sub-populations. Despite being a large proportion of the ethnic minorities living in the US, to date, there has been no comprehensive availability of tumor tissue from H/L cancer patients in national biobanks. To address this disparity, we propose to continue to develop the existing research infrastructure of the Puerto Rico Biobank (PRBB) to support research initiatives designed to understand the biological basis of cancer health disparities. The purpose of the PRBB is to facilitate the optimal collection, processing, storage, and distribution of well-annotated human biospecimens derived from the island’s H/L population for use in investigator-initiated translational cancer research. Throughout the past 10 years, a solid infrastructure has been put in place to develop this unique biorepository in Puerto Rico. Through this resource, fresh frozen tissues, paraffin blocks, high-quality tumor-derived RNA, genomic DNA, and clinical and risk factor information are available to support research at both institutions focusing on molecular aspects and determinants of cancer health disparities involving H/L living in Florida and Puerto Rico. We propose to expand the existing Partnership’s biobank via three Specific Aims. In Aim 1 we propose to continue the collection, processing, storage, and distribution of biospecimens in collaboration with local hospitals and clinics. In cooperation with the Partnership’s Outreach Core, efforts to consent healthy individuals during community outreach educational activities will continue. In Aim 2, we propose to extend the documentation of demographic, clinical, pathological, and molecular data (‘omic’, ancestry, next-gen sequence data) in collaboration with the Quantitative Sciences Core. In Aim 3, we propose to foster new collaborative research projects focused on cancer research. As facilitator of translational research, the PRBB is placed at the forefront of the Precision Medicine initiative programmatic goals of improving disease risk prediction and developing diagnosis and treatment strategies based on individual differences in genes, lifestyle, and environment, focusing on a population that is under-represented in biobanks and research.