Development of a blood pressure monitoring system based on smart-camera video recording

项目摘要 高血压在全球造成750万人死亡，没有任何警告迹象或症状， 三分之一的人超过65岁。高血压是冠心病的主要危险因素 包括缺血性和出血性中风、肾衰竭和视力损害。最具影响力的行动 预防高血压的方法是频繁测量血压（BP）， 干预和成功管理。BP监测主要发生在医疗保健提供者（HCP）处 办公室通过袖带式设备（例如血压计），只有经过培训的人员才能准确操作 人员的此外，临床血压测量有可能导致隐性和白色大衣高血压， 这两个众所周知的现象，阻止正确的BP评估和分配适当的治疗计划， 近40%的患者。其他替代方法包括动态血压监测（ABPM）和家庭血压监测。 血压测量（HBPM）设备，其由于成本、实用性和 不准确奥维德英国石油公司提出了一项创新技术，以实现全面的BP检测和管理 通过专利软件，利用当今先进的智能手机摄像头技术， 确定患者血压所需的生物标志物。该解决方案是授权的算法，估计BP 从心脏的QRS信号，这是专门通过分析病人的垂直头捕捉 运动（VHM）。此外，面部血流的速率通过以下众所周知的实践来观察： 视频体积描记（vPPG）。有了这些数据，系统就能够生产出瞬时炉膛 心率周期（THRi）和瞬时脉搏传导时间（PTTi），通过基于云的算法进行分析 在瞬间产生收缩压和舒张压以及心率。奥维德的技术 已针对临床级HBPM器械进行了体内测试，并显示出与参考器械的强相关性 用现代标准测量。在第一阶段的申请中，奥维德英国石油公司将评估 当遇到可能影响vPPG和QRS的变量时，正确检测BP的拟议方法 估计。具体活动将包括对选定的人类受试者进行研究，以验证该技术是否适用于 汞血压计，并调查年龄，性别，肤色和血压基线作为原因的作用 的错误。收集的数据将用于执行解决任何相关问题所需的算法优化 这些变量。拟议的I期研究的结论将确定奥维德BP的可行性 基于视频的方法来测量BP。在第二阶段，奥维德将进行一项更大的研究，以确定和解决 影响读数的其他关键问题，包括可能妨碍 准确评估VHM和PPG。

PROJECT SUMMARY Hypertension causes 7.5 M deaths worldwide with no warning signs or symptoms and occurs in more than two thirds of individuals over the age of 65. Hypertension represents a major risk factor for coronary heart problems including ischemic and hemorrhagic strokes, kidneys failure, and visual impairment. The most impactful action against hypertension is represented by frequent blood pressure (BP) measurements, which assure early intervention and its successful management. BP monitoring occurs mainly at the Health Care Provider’s (HCP) office through cuff-based devices (e.g. sphygmomanometer) that can only accurately be operated by trained personnel. Moreover, clinical BP measurement has the potential to cause Masked and White Coat Hypertension, two well-known phenomena that prevent correct BP assessment and assignment of a proper therapeutic plan in nearly 40% of the patients. Other alternatives are represented by ambulatory BP monitoring (ABPM) and home blood pressure measurement (HBPM) devices which have shown limitations due to costs, practicality, and inaccuracy. Ovid BP proposes an innovative technology to allow comprehensive BP detection and management via patented software that leverages today’s advanced smartphone camera technology to capture the biomarkers required to determine a patients’ BP. The solution is empowered by an algorithm that estimates BP from the heart’s QRS signal, which is specifically captured through analysis of the patients’ Vertical Head Movement (VHM). Additionally, the rate of facial blood flow is observed through the well-understood practice of video plethysmography (vPPG). With this data the system is capable of producing the Instantaneous Hearth Rate Period (THRi) and Instantaneous Pulse Transit Time (PTTi), which are analyzed by a cloud-based algorithm yielding systolic and diastolic blood pressure as well as heart rate in a matter of moments. Ovid’s technology has been tested in-vivo against clinical-grade HBPM devices and has exhibited a strong correlation to the reference measurements obtained by the modern standard. In this Phase I application, Ovid BP will assess the feasibility of the proposed approach to correctly detect BP when confronted with variables that might affect vPPG and QRS estimation. Specific activities will include a study on selected human subjects to validate the technology against a mercury sphygmomanometer and to investigate the role of age, sex, skin tone, and BP baseline as the cause of errors. Data collected will be used to perform algorithm refinements required to solve any issues associated with these variables. The conclusion of the proposed Phase I study will establish the feasibility of Ovid BP’s video-based approach to measuring BP. During Phase II, Ovid will conduct a larger study to identify and solve other key issues affecting the readings, including potential dermatological conditions that may impede the accurate assessment of both VHM and PPG.