Studies of Occupational Cancer (Pesticides)

在这个项目中有几项研究。然而，其中最大的是 农业健康研究。这项前瞻性队列研究旨在评估 农药和其他农业因素与癌症风险之间的关系， 其它疾病这项研究的招募对象包括来自爱荷华州和 北卡罗来纳州。从1993年至1997年，详细资料是通过自填问卷获得的。 调查问卷，并从1998年至2003年9月，再次从2004年至2010年的计算机 辅助电话访谈更新了登记时收集的信息。电话 访谈内容包括关于农药使用和其他农业接触、生活方式 因素、病史和家族病史以及饮食。一份针对慢性 在2010 - 2015年期间，对癌症以外的其他疾病进行了管理，重点关注慢性疾病， 由NIEHS的研究人员领导。AHS提供了一些信息， 农药与癌症的关系在本财年，发表了多篇论文， 包括一项关于膀胱癌的研究，显示芳香胺杀虫剂与膀胱癌之间的联系。 农药施用者的癌症风险。另一项评估显示， 使用异丙甲草胺与肝癌之间的关系， 啮齿动物AHS配偶是评估较低暴露的重要人群 水平，以及妇女的癌症。一项针对这一群体的研究显示， 甲状腺癌和卵巢癌与接触特定的有机磷杀虫剂有关。颊 细胞可从约50%的队列中获得，并提供基因组DNA的来源 用于GXE研究和表观遗传机制的研究。较小的子研究具有生物学 用于评估暴露和结局的中间效应的样本。今年成为 发表了一项研究，评估了端粒晶状体

There are several studies within this project. However, the largest of these is the Agricultural Health Study (AHS). This prospective cohort study was designed to evaluate the relationship between pesticides and other agricultural factors and the risk of cancer and other diseases. Enrollment in this study includes about 90,000 men and women from Iowa and North Carolina. From 1993-1997 detailed information was obtained by self-administered questionnaire and from 1998 through September 2003 and again from 2004 through 2010 computer assisted telephone interviews updated the information collected at enrollment. Telephone interviews include questions on pesticides used and other agricultural exposures, lifestyle factors, medical and family history of disease, and diet. A questionnaire focused on chronic disease other than cancer was administered in 2010-2015 and focused on chronic disease other than cancer was led by investigators from NIEHS. The AHS has provided information on a number of pesticide-cancer associations over the years. In this FY, several papers were published, including one on bladder cancer, showing a link between aromatic amine pesticides and bladder cancer risk in the pesticide applicators. Another evaluation showed an increased association between metolachlor use and liver cancer, which had been previously linked to liver cancer in rodents. The AHS spouses represent an important population in which to evaluate lower exposure levels, as well as cancer among women. A study among this group showed an increased risk of thyroid and ovarian cancers with exposure to specific organophosphate insecticides. Buccal cells are available from approximately 50% of the cohort, and provides a source of genomic DNA for GXE studies and studies of epigenetic mechanisms. Smaller sub-studies have biological specimens for the evaluation of intermediate effects of exposure and outcome. This year a study was published evaluating the association between telomere len