Yale Head and Neck Cancer SPORE Developmental Research Program

项目摘要 耶鲁大学SPORE发展研究计划（DRP）在头颈癌中的主要目标 （YHN-SPORE）是确定和资助具有转化潜力的创新试点项目， 在头颈癌领域的风险评估，早期发现，生物标志物， 预后和治疗预测，癌发生/肿瘤发生的机制，新的治疗靶点， 开发新的治疗方法和新的治疗方法。资助发展的研究人员 强烈鼓励研究项目与内部和外部的其他研究人员合作， YHN-SPORE机构，包括其他SPORE社区。目的是为每个受资助的DRP提供 有可能发展成独立的完整SPORE项目或同等规模的研究提案的项目。 最终，沿着主要的YHN-SPORE项目，该项目的成果将有助于 在美国和世界范围内降低头颈癌发病率和死亡率。DRP计划奖 委员会将成立，并将招募，评估和选择试点项目的创新建议， 头颈癌的潜在转化。每年最多三个项目将在科学和财政上得到支持。 由YHN-SPORE提供支持，定期进行进度评估。

PROJECT SUMMARY The primary goal of the Developmental Research Program (DRP) of the Yale SPORE in Head & Neck Cancer (YHN-SPORE) is to identify and fund innovative pilot projects that possess translational potential to make an impact in the field of head & neck cancer in the areas of risk assessment, early detection, biomarkers for prognosis and therapy prediction, mechanisms of carcinogenesis/tumorigenesis, novel therapeutic targets, development of novel therapeutics, and novel treatment approaches. Investigators of funded developmental research projects are strongly encouraged to collaborate with other investigators within and outside of the YHN-SPORE institutions, including other SPORE communities. The purpose is to provide each funded DRP project with the potential to evolve into independent full SPORE projects or equivalent-scale study proposals. Ultimately, along with the main YHN-SPORE projects, the outcome from this program will contribute to the reduction of head & neck cancer morbidity and mortality in the US and worldwide. A DRP Program Award Committee will be formed and will recruit, evaluate, and select innovative proposals for pilot projects with translational potential for head & neck cancer. Up to three projects per year will be scientifically and financially supported by the YHN-SPORE, with regular progress evaluation.